| Author | Pinheiro, Regina Helena Rathsam | |
| Author | Boa-Sorte, Ney | |
| Author | Grassi, Maria Fernanda Rios | |
| Author | Copello, Úrsula Cury | |
| Author | Rios, Karla Tayrine Silva Guimarães | |
| Author | Araújo, Thessika | |
| Author | Castro Filho, Bernardo Galvão | |
| Access date | 2019-08-07T13:14:53Z | |
| Available date | 2019-08-07T13:14:53Z | |
| Document date | 2019 | |
| Citation | PINHEIRO, Regina Helena Rathsam et al. Revisiting Keratoconjunctivitis sicca associated with Human T-Cell Lymphotropic Virus Type 1: prevalence, clinical aspects and proviral load. Brazilian Journal of Infectious Disease, v. 23, n. 2, p. 95-101, 2019. | pt_BR |
| ISSN | 1413-8670 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/34646 | |
| Sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) (301092/2018-4), Fundação de Amparo à Pesquisa do Estado da Bahia (Fapesb)(CNV0072/2013) and Fundação Nacional para o Desenvolvimento do Ensino Superior (Funadesp). | pt_BR |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | HTLV-1 | pt_BR |
| Subject in Portuguese | Keratoconjunctivitis sicca | pt_BR |
| Subject in Portuguese | Prevalência | pt_BR |
| Subject in Portuguese | Syndromesa olho seco | pt_BR |
| Title | Revisiting Keratoconjunctivitis sicca associated with Human T-Cell Lymphotropic Virus Type 1: prevalence, clinical aspects and proviral load | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.bjid.2019.04.002 | |
| Abstract | The prevalence of keratoconjunctivitis sicca (KCS) associated with Human T-Cell Lymphotropic Virus Type 1 (HTLV-1) (HTLV-1/KCS) has been estimated at around 37%, but its clinical manifestations are poorly described. Purpose: To determine the prevalence and associated factors of HTLV-1/KCS in a large cohortof HTLV-1-infected individuals living in Salvador, Brazil.Methods: A cross-sectional study was conducted between June 2004 and September 2017 atthe Integrative and Multidisciplinary Center for HTLV in Salvador, Bahia-Brazil. Data from758 HTLV-1-infected patients was collected. A complete ophthalmologic examination wasperformed in both eyes. Lacrimal function was evaluated by breakup time, Rose Bengaland Schirmer I Tests. KCS diagnosis was considered in the presence of at least two out ofthree positive tests. HTLV-1 proviral load Crude and Adjusted Prevalence Rates (PR) with95% Confidence Intervals (95% CI) were estimated using multivariate Poisson Regressionwith robust error variance.Results: The overall prevalence of KCS was 31.7%, with higher rates observed in HTLV-1-associated myelopathy/tropical spastic paraparesis patients (crude PR: 1.84; CI95%:1.50–2.26) even after adjusting for age, sex, time of HTLV-1 diagnosis and schooling (adjustedPR: 1.63; CI95%: 1.31–2.02). Proviral load, low corrected visual acuity, burning and/or pain anditching were all significantly higher in patients with KCS. | pt_BR |
| Affilliation | Escola Bahiana de Medicina e Saúde Pública. Centro Integrativo e Interdisciplinar de HTLV. Salvador, BA, Brazil / Instituto Brasileiro de Oftalmologia e Prevenção da Cegueira. Salvador, BA, Brazil. | pt_BR |
| Affilliation | Escola Bahiana de Medicina e Saúde Pública. Centro Integrativo e Interdisciplinar de HTLV. Salvador, BA, Brazil. | pt_BR |
| Affilliation | Escola Bahiana de Medicina e Saúde Pública. Centro Integrativo e Interdisciplinar de HTLV. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brazil. | pt_BR |
| Affilliation | Instituto Brasileiro de Oftalmologia e Prevenção da Cegueira. Salvador, BA, Brazil. | pt_BR |
| Affilliation | Instituto Brasileiro de Oftalmologia e Prevenção da Cegueira. Salvador, BA, Brazil. | pt_BR |
| Affilliation | Escola Bahiana de Medicina e Saúde Pública. Centro Integrativo e Interdisciplinar de HTLV. Salvador, BA, Brazil. | pt_BR |
| Affilliation | Escola Bahiana de Medicina e Saúde Pública. Centro Integrativo e Interdisciplinar de HTLV. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brazil. | pt_BR |
| Subject | HTLV-1 | pt_BR |
| Subject | Keratoconjunctivitis sicca | pt_BR |
| Subject | Prevalence | pt_BR |
| Subject | Dry eye syndromesa | pt_BR |
