| Author | Araújo, Clinascia Rodrigues Rocha | |
| Author | Silva, Roqueline Rodrigues | |
| Author | Silva, Thiago de Melo | |
| Author | Takahashi, Jacqueline Aparecida | |
| Author | Sales Junior, Policarpo Ademar | |
| Author | Pinto, Nisia Andrade Villela Dessimoni | |
| Author | Fagundes, Elaine Maria de Souza | |
| Author | Romanha, Alvaro José | |
| Author | Murta, Silvane Maria Fonseca | |
| Author | Alcântara, Antônio Flávio de Carvalho | |
| Access date | 2019-08-07T13:44:21Z | |
| Available date | 2019-08-07T13:44:21Z | |
| Document date | 2017 | |
| Citation | ARAÚJO, Clinascia Rodrigues Rocha et al. Constituents from stem barks of Luehea ochrophylla Mart and evaluation of their antiparasitic, antimicrobial, and antioxidant activities. Natural Product Research, v. 31, n. 16, p. 1948-1953, 2017. | pt_BR |
| ISSN | 1478-6419 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/34649 | |
| Language | eng | pt_BR |
| Publisher | Taylor & Francis Health Sciences | pt_BR |
| Rights | restricted access | pt_BR |
| Title | Constituents from stem barks of Luehea ochrophylla Mart and evaluation of their antiparasitic, antimicrobial, and antioxidant activities | pt_BR |
| Type | Article | |
| DOI | 10.1080/14786419.2016.1266346 | |
| Abstract | Luehea species are found in almost all Central and South American countries. The present work describes the phytochemical study, isolation, and structural characterisation of friedelin, β-friedelinol, lupeol, pseudotaraxasterol, β-sitosterol, betulinic acid, taraxasterol, (-)-epicatechin, β-sitosterol-3-O-β-d-glucopyranoside, and (+)-epicatechin-(4β→8)-epicatechin from stem barks of Luehea ochrophylla Mart. The structural identification of the isolated compounds was mainly performed by NMR analyses and comparison with the data from literature. These compounds were isolated for the first time in the genus Luehea, except β-sitosterol glucopyranoside, (-)-epicatechin, and lupeol. Hexane extract (HE) and dichloromethane (DF) and ethyl acetate (AF) fractions exhibited antiparasitic activity against amastigote (intracellular) and trypomastigote culture forms of Trypanosoma cruzi. The ethanol extract (EE), DF, and ethanol fraction (EF) exhibited considerable antifungal activity against Candida albicans. Moreover, extracts and fractions exhibited significant percentage of capture free radicals of 2,2-diphenyl-picrylhydrazyl (DPPH) when compared to the standard of ascorbic acid. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Exatas. Departamento de Química. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal dos Vales do Jequitinhonha e Mucuri. Departamento de Química. Diamantina, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Exatas. Departamento de Química. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Exatas. Departamento de Química. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Parasitologia Celular e Molecular. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal dos Vales do Jequitinhonha e Mucuri. Departamento de Nutrição. Diamantina, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Fisiologia e Biofísica. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Parasitologia Celular e Molecular. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Parasitologia Celular e Molecular. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Exatas. Departamento de Química. Belo Horizonte, MG, Brasil. | pt_BR |
| Subject | Luehea ochrophylla | pt_BR |
| Subject | Antimicrobial action | pt_BR |
| Subject | Antioxidant activity | pt_BR |
| Subject | Antiparasitic activity | pt_BR |
| Embargo date | 2100-01-01 | |
