Author | Barreira, Débora Maria Pires Gonçalves | |
Author | Fumian, Túlio Machado | |
Author | Tonini, Marco André Loureiro | |
Author | Volpini, Lays Paula Bondi | |
Author | Santos, Rodrigo Pratte | |
Author | Ribeiro, Anézia Lima Chaves | |
Author | Leite, José Paulo Gagliardi | |
Author | Souza, Márcia Terezinha Baroni de Moraes e | |
Author | Brasil, Patrícia | |
Author | Cunha, Denise Cotrim da | |
Author | Miagostovich, Marize Pereira | |
Author | Spano, Liliana Cruz | |
Access date | 2019-08-08T15:08:47Z | |
Available date | 2019-08-08T15:08:47Z | |
Document date | 2017 | |
Citation | BARREIRA, Débora Maria Pires Gonçalves et al. Detection and molecular characterization of the novel recombinant norovirus GII.P16-GII.4 Sydney in southeastern Brazil in 2016. Plos One, p. 1-9, Dec. 2017. | pt_BR |
ISSN | 1932-6203 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/34675 | |
Language | eng | pt_BR |
Publisher | Public Library of Science | pt_BR |
Rights | open access | pt_BR |
Title | Detection and molecular characterization of the novel recombinant norovirus GII.P16-GII.4 Sydney in southeastern Brazil in 2016 | pt_BR |
Type | Article | pt_BR |
DOI | 10.1371/journal.pone.0189504 | |
Abstract | Noroviruses are the leading cause of acute gastroenteritis (AGE) in all age groups worldwide. Despite the high genetic diversity of noroviruses, most AGE outbreaks are caused by a single norovirus genotype: GII.4. Since 1995, several different variants of norovirus GII.4 have been associated with pandemics, with each variant circulating for 3 to 8 years. The Sydney_2012 variant was first reported in Australia and then in other countries. A new variant, GII.P16-GII.4, was recently described in Japan and South Korea and then in the USA, France, Germany and England. In our study, 190 faecal specimens were collected from children admitted to a paediatric hospital and a public health facility during a surveillance study of sporadic cases of AGE conducted between January 2015 and July 2016. The norovirus was detected by RT-qPCR in 51 samples (26.8%), and in 37 of them (72.5%), the ORF1-2 junction was successfully sequenced. The new recombinant GII.P16-GII.4 Sydney was revealed for the first time in Brazil in 2016 and predominated among other strains (9 GII.Pe-GII.4, 3 GII.P17-GII.17, 1 GII.Pg-GII.1, 1 GII.P16-GII.3 and 1 GII.PNA-GII.4). The epidemiological significance of this new recombinant is still unknown, but continuous surveillance studies may evaluate its impact on the population, its potential to replace the first recombinant GII.Pe-GII.4 Sydney 2012 variant, and the emergence of new recombinant forms of GII.P16. | pt_BR |
Affilliation | Federal University of Espírito Santo. Health Science Center. Pathology Department. Laboratory of Virology and Infectious Gastroenteritis. Vitória, ES, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Federal University of Espírito Santo. Health Science Center. Pathology Department. Laboratory of Virology and Infectious Gastroenteritis. Vitória, ES, Brazil. | pt_BR |
Affilliation | Federal University of Espírito Santo. Health Science Center. Pathology Department. Laboratory of Virology and Infectious Gastroenteritis. Vitória, ES, Brazil. | pt_BR |
Affilliation | Federal University of Espírito Santo. Health Science Center. Pathology Department. Laboratory of Virology and Infectious Gastroenteritis. Vitória, ES, Brazil. | pt_BR |
Affilliation | Central Laboratory of Public Health. Vitória, ES, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Doenças Febris Agudas. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sérgio Arouca. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Federal University of Espírito Santo. Health Science Center. Pathology Department. Laboratory of Virology and Infectious Gastroenteritis. Vitória, ES, Brazil. | pt_BR |
Subject | Norovirus GII.P16-GII.4 Sydney | pt_BR |
Subject | Southeastern Brazil | pt_BR |
Subject | Brazil | pt_BR |
Subject | Noroviruses | pt_BR |
e-ISSN | 1932-6203 | |