Author | Bravo, Bruna Souza Felix | |
Author | Azulay, David Rubem | |
Author | Luiz, Ronir Raggio | |
Author | Mandarim-De-Lacerda, Carlos Alberto | |
Author | Cuzzi, Tullia | |
Author | Manela-Azulay, Mônica | |
Access date | 2019-08-12T13:41:53Z | |
Available date | 2019-08-12T13:41:53Z | |
Document date | 2015 | |
Citation | BRAVO, Bruna Souza Felix et al. Oral isotretinoin in photoaging: objective histological evidence of effi cacy and durability. Anais Brasileiros de Dermatologia, v. 90, n. 3, p. 394-396, 2015. | pt_BR |
ISSN | 0365-0596 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/34726 | |
Description | Tulia Cuzzi. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento. | pt_BR |
Language | eng | pt_BR |
Publisher | Sociedade Brasileira de Dermatologia | pt_BR |
Rights | open access | pt_BR |
Title | Oral isotretinoin in photoaging: objective histological evidence of efficacy and durability | pt_BR |
Type | Article | pt_BR |
DOI | 10.1590/abd1806-4841.20153703 | |
Abstract | BACKGROUND: The off-label use of oral isotretinoin in photoaging is a therapeutic tool that has been used
by dermatologists. There are few studies to corroborate its effectiveness and durability. OBJECTIVES: To assess, both clinically and histologically, the changes caused by the use of oral isotretinoin in skin photoaging as well as the duration of the effects. METHODS: 20 female patients, aged 45-50 years, with phototypes II-VI, none of whom had experienced menopause, were treated with 20mg oral isotretinoin, 3 days a week, for 12 weeks. They underwent clinical analysis and skin biopsies in the pre-auricular region, while histologic cuts enabled assessment of the solar elastosis level and morphologic analysis. RESULTS: Clinically, patients, as well as the researching and the assessor physicians, noticed improvement in skin quality. One patient presented severe solar elastosis, 11 manifested the moderate form, while 8 presented the discreet type. According to histological analysis, 65% of the patients revealed alteration in the distribution and thickness of the elastic fi bers, which can be interpreted as a histological improvement, while 60% showed an increase
in collagen density. We observed an increase in collagen density, from 51.2% to 57.4%, (p=0.004). At the end of the 12-week follow-up period, this density decreased to 54.7% (p=0.050). There was an increase in the density of elastic fibers, from 26.5% to 31.3%, (p=0.02), which had dropped to 27.5% at the end of the 12- week follow-up period. CONCLUSIONS: The study confirmed the role of oral isotretinoin in remodeling the extracellular matrix against photoaging, as well as its durability after 12 weeks, especially when we consider collagen fibers. | pt_BR |
Affilliation | Santa Casa de Misericórdia do Rio de Janeiro. Instituto de Dermatologia Professor Rubem David Azulay. Rio de Janeiro, RJ, Brasil / Hospital Federal da Lagoa. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Santa Casa de Misericórdia do Rio de Janeiro. Instituto de Dermatologia Professor Rubem David Azulay. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade do Estado do Rio de Janeiro. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Isotretinoin | pt_BR |
Subject | Retinoids | pt_BR |
Subject | Skin aging | pt_BR |