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| Autor | Kumar, Nathella Pavan | |
| Autor | Fukutani, Kiyoshi Ferreira | |
| Autor | Shruthi, Basavaradhya S. | |
| Autor | Alves, Thabata | |
| Autor | Mattos, Paulo Sérgio de Morais da Silveira | |
| Autor | Rocha, Michael Santos | |
| Autor | West, Kim | |
| Autor | Natarajan, Mohan | |
| Autor | Viswanathan, Vijay | |
| Autor | Babu, Subash | |
| Autor | Andrade, Bruno de Bezerril | |
| Autor | Kornfeld, Hardy | |
| Fecha de acceso | 2019-08-12T18:10:13Z | |
| Fecha de disponibilización | 2019-08-12T18:10:13Z | |
| Fecha de publicación | 2019 | |
| Referencia | KUMAR, Nathella Pavan et al. Persistent inflammation during anti-tuberculosis treatment with diabetes comorbidity. eLife, v. 8, p. 1-19, 2019. | pt_BR |
| ISSN | 2050-084X | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/34746 | |
| Promoción | Ethics Committee of the Prof. M. Viswanathan Diabetes Research Centre (ECR/51/INST/TN/2013/MVDRC/01). The Brazilian cohort study was approved by the Ethics Committee of the Maternidade Climério de Oliveira, Federal University of Bahia (CAAE: 0115.0.054.000-09). | pt_BR |
| Idioma | eng | pt_BR |
| Editor | eLife Sciences Publications | pt_BR |
| Derechos de autor | open access | pt_BR |
| Palabras clave en Portugués | Citocinas | pt_BR |
| Palabras clave en Portugués | Diabetes mellitus | pt_BR |
| Palabras clave en Portugués | Humano | pt_BR |
| Palabras clave en Portugués | Imunologia | pt_BR |
| Palabras clave en Portugués | Doença infecciosa | pt_BR |
| Palabras clave en Portugués | Inflamação | pt_BR |
| Palabras clave en Portugués | Microbiologia | pt_BR |
| Palabras clave en Portugués | Tuberculose | pt_BR |
| Título | Persistent inflammation during anti-tuberculosis treatment with diabetes comorbidity | pt_BR |
| Tipo del documento | Article | pt_BR |
| DOI | 10.7554/eLife.46477 | |
| Resumen en Inglés | Diabetes mellitus (DM) increases risk for pulmonary tuberculosis (TB) and adverse treatment outcomes. Systemic hyper-inflammation is characteristic in people with TB and concurrent DM (TBDM) at baseline, but the impact of TB treatment on this pattern has not been determined. We measured 17 plasma cytokines and growth factors in longitudinal cohorts of Indian and Brazilian pulmonary TB patients with or without DM. Principal component analysis revealed virtually complete separation of TBDM from TB individuals in both cohorts at baseline, with hyper-inflammation in TBDM that continued through treatment completion at six months. By one year after treatment completion, there was substantial convergence of mediator levels between groups within the India cohort. Non-resolving systemic inflammation in TBDM comorbidity could reflect delayed lesion sterilization or non-resolving sterile inflammation. Either mechanism portends unfavorable long-term outcomes including risk for recurrent TB and for damaging immune pathology. | pt_BR |
| Afiliación | National Institutes of Health. National Institute for Research in Tuberculosis. International Center for Excellence in Research. Chennai, India. | pt_BR |
| Afiliación | Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brazil / Faculdade de Tecnologia e Ciências. Salvador, BA, Brazil. | pt_BR |
| Afiliación | Prof. M. Viswanathan Diabetes Research Center. Chennai, India. | pt_BR |
| Afiliación | Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research. Salvador, BA, Brazil / Universidade Salvador. Laureate Universities. Salvador, BA, Brasil. | pt_BR |
| Afiliación | Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research. Salvador, BA, Brazil / Faculdade de Tecnologia e Ciências. Salvador, BA, Brazil. | pt_BR |
| Afiliación | Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research. Salvador, BA, Brazil. | pt_BR |
| Afiliación | University of Massachusetts Medical School. Worcester, United States. | pt_BR |
| Afiliación | National Institute for Research in Tuberculosis. Chennai, India. | pt_BR |
| Afiliación | Prof. M. Viswanathan Diabetes Research Center. Chennai, India. | pt_BR |
| Afiliación | National Institutes of Health. National Institute for Research in Tuberculosis. International Center for Excellence in Research. Chennai, India. | pt_BR |
| Afiliación | Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brazil / Faculdade de Tecnologia e Ciências. Salvador, BA, Brazil / Universidade Salvador. Laureate Universities. Salvador, BA, Brasil. | pt_BR |
| Afiliación | University of Massachusetts Medical School. Worcester, United States. | pt_BR |
| Palavras clave en Inglês | Cytokines | pt_BR |
| Palavras clave en Inglês | Diabetes mellitus | pt_BR |
| Palavras clave en Inglês | Human | pt_BR |
| Palavras clave en Inglês | Immunology | pt_BR |
| Palavras clave en Inglês | Infectious disease | pt_BR |
| Palavras clave en Inglês | Inflammation | pt_BR |
| Palavras clave en Inglês | Microbiology | pt_BR |
| Palavras clave en Inglês | Tuberculosis | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar |
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