| Author | Guerra, Sylvia F. S. | |
| Author | Linhares, Alexandre C. | |
| Author | Mascarenhas, Joana D'Arc P. | |
| Author | Oliveira, Alessilva | |
| Author | Justino, Maria Cleonice A. | |
| Author | Soares, Luana S. | |
| Author | Müller, Elza Caroline | |
| Author | Brasil, Patrícia | |
| Author | Tuboi, Suely | |
| Author | Ortega-Barria, Eduardo | |
| Author | Colindres, Rómulo | |
| Access date | 2019-08-21T14:08:34Z | |
| Available date | 2019-08-21T14:08:34Z | |
| Document date | 2015 | |
| Citation | GUERRA, Sylvia F. S. et al. Rotavirus strain surveillance for three years following the introduction of rotavirus vaccine into Belém, Brazil. Journal of Medical Virology, v. 87, n. 8, p.1303-1310, Aug. 2015. | pt_BR |
| ISSN | 0146-6615 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/34924 | |
| Language | eng | pt_BR |
| Publisher | Wiley | pt_BR |
| Rights | open access | pt_BR |
| Title | Rotavirus strain surveillance for three years following the introduction of rotavirus vaccine into Belém, Brazil | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1002/jmv.24183 | |
| Abstract | The monovalent human rotavirus (RV) vaccine, RIX4414 (Rotarix™, GlaxoSmithKline Biologicals) was introduced into Brazil's Expanded Program on Immunization in March 2006. One year after vaccine introduction, the G2P[4] strain was found to be predominant, with an apparent extinction of many non-G2 strains. This study investigated the diversity of circulating strains in the three years following RIX4414 introduction. Between May 2008 and May 2011, stool samples were collected from children aged ≥12 weeks who were hospitalized for severe lab confirmed RV-gastroenteritis (≥3 liquid or semi-liquid motions over a 24-h period for <14 days, requiring ≥1 overnight hospital stay and intravenous rehydration therapy) in Belém, Brazil. RV-gastroenteritis was detected by ELISA and the G- and P-types were determined by RT-PCR assays. During the first year of surveillance nucleotide sequencing was used for typing those samples not previously typed by RT-PCR. A total of 1,726 of 10,030 severe gastroentertis hospitalizations (17.2%) were due to severe RVGE. G2P[4] was detected in 57.2% of circulating strains over the whole study period, however it predominated during the first 20 months from May 2008 to January 2009. G1P[8] increased in the last part of the study period from May 2010 to May 2011 and represented 36.6% (112/306) of the circulating strains. G2P[4] was the predominant RV strain circulating during the first 20 months of the study, followed by G1P[8]. These findings probably reflect a natural fluctuation in RV strains over time, rather than a vaccine-induced selective pressure. | pt_BR |
| Affilliation | Health Surveillance Secretariat. Evandro Chagas Institute. Belém, PA, Brazil. | pt_BR |
| Affilliation | Health Surveillance Secretariat. Evandro Chagas Institute. Belém, PA, Brazil. | pt_BR |
| Affilliation | Health Surveillance Secretariat. Evandro Chagas Institute. Belém, PA, Brazil. | pt_BR |
| Affilliation | Health Surveillance Secretariat. Evandro Chagas Institute. Belém, PA, Brazil. | pt_BR |
| Affilliation | Health Surveillance Secretariat. Evandro Chagas Institute. Belém, PA, Brazil. | pt_BR |
| Affilliation | Health Surveillance Secretariat. Evandro Chagas Institute. Belém, PA, Brazil. | pt_BR |
| Affilliation | Health Surveillance Secretariat. Evandro Chagas Institute. Belém, PA, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | GlaxoSmithKline. Rio de Janeiro, RJ, Brazil. | pt_BR |
| Affilliation | GlaxoSmithKline. Panama, Panama. | pt_BR |
| Affilliation | GlaxoSmithKline. Rio de Janeiro, RJ, Brazil. | pt_BR |
| Subject | Rotavirus | pt_BR |
| Subject | Belém | pt_BR |
| Subject | Brazil | pt_BR |
| Subject | Genotypes | pt_BR |
| Subject | Post-vaccination | pt_BR |
| Subject | Gastroenteritis | pt_BR |
| e-ISSN | 1096-9071 | |
| Embargo date | 2020-08-21 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
