Author | Ferreira, Marcel T. | |
Author | Leite, Nathalie C. | |
Author | Cardoso, Claudia R.L. | |
Author | Salles, Gil F. | |
Access date | 2019-08-28T12:14:37Z | |
Available date | 2019-08-28T12:14:37Z | |
Document date | 2015 | |
Citation | FERREIRA, Marcel T. et al. Correlates of aortic stiffness progression in patients with type 2 diabetes: importance of glycemic control: the Rio de Janeiro type 2 diabetes cohort study. Diabetes Care, v. 38, p. 897-904, May 2015. | pt_BR |
ISSN | 0149-5992 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/35151 | |
Description | Marcel T. Ferreira. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento. | pt_BR |
Language | eng | pt_BR |
Publisher | American Diabetes Association | pt_BR |
Rights | open access | pt_BR |
Title | Correlates of aortic stiffness progression in patients with type 2 diabetes: importance of glycemic control | pt_BR |
Type | Article | pt_BR |
DOI | 10.2337/dc14-2791 | |
Abstract | OBJECTIVE: The correlates of serial changes in aortic stiffness in patients with diabetes have never been investigated. We aimed to examine the importance of glycemic control on progression/regression of carotid-femoral pulse wave velocity (cf-PWV) in type 2 diabetes. RESEARCH DESIGN AND METHODS: In a prospective study, two cf-PWV measurements were performed with the Complior equipment in 417 patients with type 2 diabetes over a mean follow-up of 4.2 years. Clinical laboratory data were obtained at baseline and throughout follow-up. Multivariable linear/logistic regressions assessed the independent correlates of changes in cf-PWV. RESULTS: Median cf-PWV increase was 0.11 m/s per year (1.1% per year). Overall, 212 patients (51%) increased/persisted with high cf-PWV, while 205 (49%) reduced/persisted with low cf-PWV. Multivariate linear regression demonstrated direct associations between cf-PWV changes and mean HbA1c during follow-up (partial correlation 0.14, P = 0.005). On logistic regression, a mean HbA1c ‡7.5% (58 mmol/mol) was
associated with twofold higher odds of having increased/persistently high cf-PWV during follow-up. Furthermore, the rate of HbA1c reduction relative to baseline levels was inversely associated with cf-PWV changes (partial correlation 20.11, P = 0.011) and associated with reduced risk of having increased/persistently high aortic stiffness (odds ratio 0.82 [95% CI 0.69–0.96]; P = 0.017). Other independent correlates of progression in aortic stiffness were increases in systolic blood pressure and heart rate between the two cf-PWV measurements, older age, female sex, and presence of dyslipidemia and retinopathy. CONCLUSIONS: Better glycemic control, together with reductions in blood pressure and heart rate,was themost important correlate to attenuate/prevent progression of aortic stiffness in patients with type 2 diabetes. | pt_BR |
Affilliation | Sem afiliação. | pt_BR |
Affilliation | Sem afiliação. | pt_BR |
Affilliation | Sem afiliação. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. University Hospital Clementino Fraga Filho. Rio de Janeiro, RJ, Brazil / Universidade Federal do Rio de Janeiro. School of Medicine. Department of Internal Medicine. Rio de Janeiro, RJ, Brazil . | pt_BR |
Subject | Diabetes | pt_BR |
Subject | Type 2 diabetes | pt_BR |
Subject | Aortic stiffness | pt_BR |
Subject | Glycemic control | pt_BR |
e-ISSN | 1935-5548 | |
Embargo date | 2020-08-28 | |