| Author | Greer, Amy E. | |
| Author | Ou, San-San | |
| Author | Wilson, Ethan | |
| Author | Piwowar-Manning, Estelle | |
| Author | Forman, Michael S. | |
| Author | McCauley, Marybeth | |
| Author | Gamble, Theresa | |
| Author | Ruangyuttikarn, Cholticha | |
| Author | Hosseinipour, Mina C. | |
| Author | Kumarasamy, Nagalingeswaran | |
| Author | Nyirenda, Mulinda | |
| Author | Grinsztejn, Beatriz | |
| Author | Pilotto, Jose Henrique | |
| Author | Kosashunhanan, Natthapol | |
| Author | Gonçalves de Melo, Marineide | |
| Author | Makhema, Joseph | |
| Author | Akelo, Victor | |
| Author | Panchia, Ravindre | |
| Author | Badal-Faesen, Sharlaa | |
| Author | Chen, Ying Q. | |
| Author | Cohen, Myron S. | |
| Author | Eshleman, Susan H. | |
| Author | Thio, Chloe L. | |
| Author | Valsamakis, Alexandra | |
| Access date | 2019-08-28T14:22:04Z | |
| Available date | 2019-08-28T14:22:04Z | |
| Document date | 2017 | |
| Citation | GREER, Amy E. et al. A comparison of hepatitis B virus infection in HIV-infected and HIV-uninfected participants enrolled in a multi-national clinical trial: HPTN 052. Journal of Acquired Immune Deficiency Syndromes, v. 76, n. 4, p. 1-16, Dec. 2017. | |
| URI | https://www.arca.fiocruz.br/handle/icict/35158 | |
| Language | eng | en_US |
| Publisher | Lippincott, Williams & Wilkins | |
| Later version | https://www.arca.fiocruz.br/handle/icict/25438 | |
| Rights | open access | |
| Subject in Portuguese | HIV | pt_BR |
| Title | A comparison of hepatitis B virus infection in HIV-infected and HIV-uninfected participants enrolled in a multinational clinical trial: HPTN 052 | en_US |
| Type | Preprint | |
| DOI | 10.1097/QAI.0000000000001511 | |
| Abstract | Objective — Data comparing hepatitis B virus (HBV) infection in HIV-infected [HIV(+)], and HIV-uninfected [HIV(−)] individuals recruited into the same study are limited. HBV infection status and chronic hepatitis B (cHB) were characterized in a multi-national clinical trial: HIV Prevention Trials Network (HPTN 052). Method — HBV infection status at enrollment was compared between HIV(+) (N=1241) and HIV(−) (N=1232) from seven HBV-endemic countries. Hepatitis B e antigen (HBeAg) and plasma HBV DNA were determined in cHB. Median CD4, median plasma HIV RNA, and prevalence of transaminase elevation were compared in HIV(+) with and without cHB. Significance was assessed with Chi-square, Fisher’s exact, and median tests. Results — Among all participants, 33.6% had HBV exposure without cHB (8.9% isolated HBV core antibody, “HBcAb”; 24.7% HBcAb and anti-HB surface antibody positive, “recovered”), 4.3% had cHB, 8.9% were vaccinated, and 53.5% were uninfected. Data were similar among HIV(+) and HIV(−) except for isolated HBV core antibody (HBcAb), which was more prevalent in HIV(+) than HIV(−) [10.1% vs. 7.7%, P=0.046]. Median HBV DNA trended higher in HIV(+) than in HIV(−). In HIV(+) with cHB versus those without cHB, transaminase elevations were more prevalent (ALT ≤ Grade 2, 12% vs. 5.2%, P=0.037; AST ≤ Grade 2, 26% vs. 6.0%, P<0.001), CD4 trended lower, and HIV RNA was similar. Conclusions — HBV infection status did not differ by HIV infection status. HIV co-infection was associated with isolated HBcAb and a trend of increased HBV DNA. In HIV, cHB was associated with mild transaminase elevations and a trend toward lower CD4. | en_US |
| Affilliation | Johns Hopkins Hospital. Department of Pathology. Baltimore, MD USA. | |
| Affilliation | Fred Hutchinson Cancer Research Center. Vaccine and Infectious Disease Division. Seattle, WA, USA. | |
| Affilliation | Fred Hutchinson Cancer Research Center. Vaccine and Infectious Disease Division. Seattle, WA, USA. | |
| Affilliation | Johns Hopkins Hospital. School of Medicine. Department of Pathology. Baltimore, MD USA. | |
| Affilliation | Johns Hopkins Hospital. Department of Pathology. Baltimore, MD USA. | |
| Affilliation | FHI 360. Washington, DC, USA. | |
| Affilliation | FHI 360. Durham, NC, USA. | |
| Affilliation | Chiang Mai University. Research Institute for Health Sciences. Chaing Mai, Thailand. | |
| Affilliation | University of North Carolina. Chapel Hill, NC, USA / UNC Project-Malawi, Institute for Global Health and Infectious Diseases, Lilongwe, Malawi. | |
| Affilliation | YRGCARE Medical Centre, VHS. Chennai, India. | |
| Affilliation | College of Medicine-Johns Hopkins Project. Blantyre, Malawi. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Hospital Geral de Nova Iguaçu. Nova Iguaçu, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Chiang Mai University. Research Institute for Health Sciences. Chiang Mai, Thailand. | |
| Affilliation | Hospital Nossa Senhora da Conceição. Porto Alegre RS, Brasil. | |
| Affilliation | Botswana Harvard AIDS Institute. Gaborone, Botswana. | |
| Affilliation | Kenya Medical Research Institute. Kisumu, Kenya / Center for Disease Control. Kisumu, Kenya. | |
| Affilliation | University of the Witwatersrand. Perinatal HIV Research Unit. Johannesburg, South Africa / Soweto HPTN CRS. Soweto, South Africa. | |
| Affilliation | University of the Witwatersrand. Johannesburg, South Africa. | |
| Affilliation | Fred Hutchinson Cancer Research Center. Vaccine and Infectious Disease Division. Seattle, WA, USA. | |
| Affilliation | University of North Carolina. Department of Medicine. Chapel Hill, NC, USA | |
| Affilliation | Johns Hopkins Hospital. School of Medicine. Department of Pathology. Baltimore, MD USA. | |
| Affilliation | Johns Hopkins Hospital. School of Medicine. Department of Medicine. Baltimore, MD USA. | |
| Affilliation | Johns Hopkins Hospital. School of Medicine. Department of Pathology. Baltimore, MD USA. | |
| Subject | HIV | en_US |
| Subject | HBV | en_US |
| Subject | CD4 cell count | en_US |
| Subject | Chronic HBV infection | en_US |
| Subject | Endemic HBV | en_US |
| Subject | Prevalence of HBV infection | en_US |
| Subject | HIV-HBV co-infection | en_US |
