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AutorSilva, Gilberto Marcelo Sperandio da
AutorMediano, Mauro Felippe Felix
AutorBrasil, Pedro Emmanuel Alvarenga Americano do
AutorChambela, Mayara da Costa
AutorSilva, Joyce Almeida da
AutorSousa, Andrea Silvestre de
AutorXavier, Sergio Salles
AutorCosta, Andrea Rodrigues da
AutorSaraiva, Roberto Magalhães
AutorHasslocher-Moreno, Alejandro Marcel
Fecha de acceso2019-08-28T15:09:31Z
Fecha de disponibilización2019-08-28T15:09:31Z
Fecha de publicación2014
ReferenciaSILVA, Gilberto Marcelo Sperandio da et al. A clinical adverse drug reaction prediction model for patients with Chagas disease treated with benznidazole. Antimicrobial Agents and Chemotherapy, v. 58, n. 11, p. 6371-6377, Nov. 2014.pt_BR
ISSN0066-4804pt_BR
URIhttps://www.arca.fiocruz.br/handle/icict/35162
Idiomaengpt_BR
EditorAmerican Society for Microbiologypt_BR
Derechos de autoropen accesspt_BR
TítuloA clinical adverse drug reaction prediction model for patients with Chagas disease treated with benznidazolept_BR
Tipo del documentoArticlept_BR
DOI10.1128/AAC.02842-14
Resumen en InglésBenznidazole (BZN) is the main trypanocidal drug used to treat Chagas disease, and the evidence supporting the benefits of BZN use during the chronic phase of the disease will favor its use in millions of individuals. However, more than 30% of patients treated with BZN may suffer adverse drug reactions (ADRs), and the development of tools to identify those patients at risk is highly desirable. In the present study, we aimed to identify predictive factors for ADRs in Chagas disease patients treated with BZN. Among 195 patients included in the study, 48.7% experienced ADRs and 31.3% had ADRs that caused BZN treatment discontinuation. Overall ADRs and ADRs that caused BZN treatment discontinuation were more common among women and in those who graduated from elementary school. Overall ADRs were also less frequent among black individuals. Based on logistic regression analysis, female sex (odds ratio [OR], 2.9; 95% confidence interval [CI], 1.5 to 5.4), graduation from elementary school (OR, 2.0; 95% CI, 1.1 to 3.8), and white (OR, 5.0; 95% CI, 1.0 to 24.1) and mulatto (OR, 5.6; 95% CI, 1.1 to 28.7) races were considered to predict overall ADRs, and female sex (OR, 2.3; 95% CI, 1.2 to 4.3) was considered to predict ADRs that caused BZN treatment discontinuation. Graduation from elementary school also presented a tendency to predict ADRs that caused BZN treatment discontinuation (OR, 1.8; 95% CI, 0.9 to 3.6). The logistic regression (LR) models to predict ADRs to BZN described in this study may become important tools to minimize ADRs and improve patients’ compliance and thus assist physicians treating patients with Chagas disease with BZN.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Nacional de infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Nacional de infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Nacional de infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Nacional de infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Nacional de infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Nacional de infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Nacional de infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Nacional de infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Nacional de infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Nacional de infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.pt_BR
Palavras clave en InglêsChagas diseasept_BR
Palavras clave en InglêsBenznidazolept_BR
Palavras clave en InglêsClinical adverse drug reactionpt_BR
e-ISSN1098-6596
Fecha de embargo2020-08-28


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