| Author | Morgado, Sergio | |
| Author | Vicente, Ana Carolina | |
| Access date | 2019-09-03T12:45:44Z | |
| Available date | 2019-09-03T12:45:44Z | |
| Document date | 2019 | |
| Citation | MORGADO, Sergio; VICENTE, Ana Carolina. Global In-Silico Scenario of tRNA Genes and Their Organization in Virus Genomes. Viruses, v. 11, n. 180, 14p, Feb. 2019. | pt_BR |
| ISSN | 1999-4915 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/35292 | |
| Language | eng | pt_BR |
| Publisher | MDPI | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Vírus | pt_BR |
| Subject in Portuguese | Bacteriófagos | pt_BR |
| Subject in Portuguese | Especificidade de Hospedeiro | pt_BR |
| Subject in Portuguese | Códon | pt_BR |
| Title | Global In-Silico Scenario of tRNA Genes and Their Organization in Virus Genomes | pt_BR |
| Type | Article | |
| DOI | 10.3390/v11020180 | |
| Abstract | Viruses are known to be highly dependent on the host translation machinery for their
protein synthesis. However, tRNA genes are occasionally identified in such organisms, and in
addition, few of them harbor tRNA gene clusters comprising dozens of genes. Recently, tRNA gene
clusters have been shown to occur among the three domains of life. In such a scenario, the viruses
could play a role in the dispersion of such structures among these organisms. Thus, in order to reveal
the prevalence of tRNA genes as well as tRNA gene clusters in viruses, we performed an unbiased
large-scale genome survey. Interestingly, tRNA genes were predicted in ssDNA (single-stranded
DNA) and ssRNA (single-stranded RNA) viruses as well in many other dsDNA viruses of families
from Caudovirales order. In the latter group, tRNA gene clusters composed of 15 to 37 tRNA genes
were characterized, mainly in bacteriophages, enlarging the occurrence of such structures within
viruses. These bacteriophages were from hosts that encompass five phyla and 34 genera. This in-silico
study presents the current global scenario of tRNA genes and their organization in virus genomes,
contributing and opening questions to be explored in further studies concerning the role of the
translation apparatus in these organisms. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microrganismos. Rio de Janeiro. RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microrganismos. Rio de Janeiro. RJ, Brasil. | pt_BR |
| Subject | tRNA gene | pt_BR |
| Subject | tRNA gene cluster | pt_BR |
| Subject | Virus | pt_BR |
| Subject | Bacteriophages | pt_BR |
| Subject | ssRNA | pt_BR |
| Subject | Translation apparatus | pt_BR |
| Subject | Host range | pt_BR |
| Subject | Codons | pt_BR |
| Subject | ssDNA | pt_BR |
| DeCS | Especificidade de Hospedeiro | pt_BR |
| DeCS | Alanina-tRNA Ligase | pt_BR |
| DeCS | Códon | pt_BR |
| e-ISSN | 1999-4915 | |
