| Author | Soares, Emmanuel Alves | |
| Author | Lazera, Márcia dos Santos | |
| Author | Wanke, Bodo | |
| Author | Ferreira, Marcela de Faria | |
| Author | Oliveira, Raquel de Vasconcellos Carvalhaes de | |
| Author | Oliveira, Adeno Gonçalves | |
| Author | Coutinho, Ziadir Francisco | |
| Access date | 2019-09-11T14:04:04Z | |
| Available date | 2019-09-11T14:04:04Z | |
| Document date | 2019 | |
| Citation | SOARES, Emmanuel Alves et al. Mortality by cryptococcosis in Brazil from 2000 to 2012: a descriptive epidemiological study. Plos Neglected Tropical Diseases, p. 1-17, July 2019. | pt_BR |
| ISSN | 1935-2727 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/35495 | |
| Language | eng | pt_BR |
| Publisher | Public Library of Science | pt_BR |
| Rights | open access | pt_BR |
| Title | Mortality by cryptococcosis in Brazil from 2000 to 2012: a descriptive epidemiological study | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1371/journal.pntd.0007569 | |
| Abstract | Background: Cryptococcosis is a neglected and predominantly opportunistic mycosis that, in Brazil, poses an important public health problem, due to its late diagnosis and high lethality. Methods: The present study analysed cryptococcosis mortality in Brazil from January 2000 to December 2012, based on secondary data (Mortality Information System/SIM-DATASUS and IBGE). Results: Out of 5,755 recorded deaths in which cryptococcosis was mentioned as one of the morbid states that contributed to death, two distinct groups emerged: 1,121 (19.5%) registered cryptococcosis as the basic cause of death, and 4,634 (80.5%) registered cryptococcosis associated with risk factors, mainly AIDS (75%), followed by other host risks (5.5%). The
mortality rate by cryptococcosis as the basic cause was 6.19/million inhabitants, whereas the mortality rate by cryptococcosis as an associated cause was 25.19/million inhabitants. Meningitis was the predominant clinical form (80%), males were the more affected (69%), and 39.5 years old was the mean age. The highest mortality rate due to cryptococcosis as basic cause occurred in the state of Mato Grosso (10.96/million inhabitants). Mortality rates due to cryptococcosis as associated cause were highest in the states of Santa Catarina
(70.41/million inhabitants) and Rio Grande do Sul (64.40/million inhabitants), both in the South Region. Southeast, Northeast and South showed significant time trends in mortality rates. Conclusions: This study is relevant because it shows the magnitude of cryptococcosis mortality linked to AIDS and removes the invisibility of a particular non-AIDS-related disease, accounting for almost 20% of all cryptococcosis deaths. It can also contribute to control and surveillance programs, beyond highlighting the urgent prioritization of early diagnosis and proper treatment to reduce the unacceptable mortality rate of this neglected mycosis in Brazil. | pt_BR |
| Affilliation | State Secretary of Health of Piauí. Natan Portela Institute of Tropical Diseases. Departament of infectious disease. Teresina, PI, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | State Secretary of Health of Piauí. Natan Portela Institute of Tropical Diseases. Departament of infectious disease. Teresina, PI, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sérgio Arouca. Centro de Saúde Escola Germano Sinval Faria. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Cryptococcosis | pt_BR |
| Subject | Mortality | pt_BR |
| Subject | Brazil | pt_BR |
| e-ISSN | 1935-2727 | |
