| Author | Moraes, Marcia Terezinha Baroni de | |
| Author | Olivares, Alberto Ignácio Olivares | |
| Author | Fialho, Alexandre Madi | |
| Author | Malta, Fábio Correia | |
| Author | Mouta Junior, Sergio da Silva e | |
| Author | Bispo, Romanul de Souza | |
| Author | Velloso, Alvaro Jorge | |
| Author | Leitão, Gabriel Azevedo Alves | |
| Author | Cantelli, Carina Pacheco | |
| Author | Nordgren, Johan | |
| Author | Svenson, Lennart | |
| Author | Miagostovich, Marize Pereira | |
| Author | Leite, José Paulo G. | |
| Access date | 2019-09-17T12:00:00Z | |
| Available date | 2019-09-17T12:00:00Z | |
| Document date | 2019 | |
| Citation | MORAES, Marcia Therezinha Baroni de et al. Phenotyping of Lewis and secretor HBGA from saliva and detection of new FUT2 gene SNPs from young children from the Amazon presenting acute gastroenteritis and respiratory infection. Infection, Genetics and Evolution , v. 70, p. 61–66, Feb. 2019. | pt_BR |
| ISSN | 1567-1348 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/35623 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Antígenos do grupo histo-sangue | pt_BR |
| Subject in Portuguese | Saliva, secretor fraco | pt_BR |
| Subject in Portuguese | Polimorfismos de nucleotídeo único | pt_BR |
| Subject in Portuguese | Amazônia | pt_BR |
| Title | Phenotyping of Lewis and secretor HBGA from saliva and detection of new FUT2 gene SNPs from young children from the Amazon presenting acute gastroenteritis and respiratory infection | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.meegid.2019.02.011 | |
| Abstract | The Histo-blood group antigens (HBGA) are host genetic factors associated with susceptibility to rotavirus (RV) and human norovirus (HuNoV), the major etiological agents of viral acute gastroenteritis (AGE) worldwide. The FUT2 gene expressing the alpha-1, 2-L- fucosyltransferase enzyme is important for gut HBGA expression, and also provides a composition of the phenotypic profile achieved through mutations occurring in populations with different evolutionary histories; as such, it can be considered a genetic population marker. In this study, Lewis and secretor HBGA phenotyping was performed using 352 saliva samples collected from children between three months and five years old born in the Amazon (Brazil, Venezuela and English Guyana) presenting AGE or acute respiratory infection (ARI), the latter considered as control samples. The total of children phenotyped as secretors was 323, corresponding to 91.80%. From these, 207 (58.80%) had a Le (a + b+) profile. The HBGA profiles were equally found in children with AGE as well as with ARI. The rs1047781 of the FUT2 gene was not detected in DNA from saliva cells with a Le (a+b+) profile. However, mutations not yet described in the FUT2 gene were observed: missense 325A>T, 501C>T, 585C>T, 855A>T and missense substitutions 327C>T [S (Ser) > C (Cys)], 446 T>C [L(Leu) > P(Pro)], 723C>A [N(Asn) > K(Lys)], 724A>T [I(Ile) > F(Phe)], 736C>A [H(His) > N(Asn)]. The SNP distribution in the FUT2 gene of the analyzed samples was very similar to that described in Asian populations, including indigenous tribes. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Roraima. Centro de Pesquisa Observatório da Saúde Roraima.Boa Vista, RR, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Programa de Pós-Graduação em Biologia Parasitária. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Roraima. Centro de Pesquisa Observatório da Saúde Roraima.Boa Vista, RR, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Departamento de Vacinas Virais e Departamento de Controle de Qualidade. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Programa de Pós-Graduação em Biologia Parasitária. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Departamento de Vacinas Virais e Departamento de Controle de Qualidade. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Linköping University. Department of Clinical and Experimental Medicine. Division of Molecular Virology. Linköping, Sweden. | pt_BR |
| Affilliation | Linköping University. Department of Clinical and Experimental Medicine. Division of Molecular Virology. Linköping, Sweden. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Histo-blood group antigens | pt_BR |
| Subject | Saliva, weak secretor | pt_BR |
| Subject | Single nucleotide polymorphisms | pt_BR |
| Subject | Amazon | pt_BR |
| e-ISSN | 1567-7257 | |
| Embargo date | 2025-01-01 | |
