| Author | Dias, Gleiston G. | |
| Author | Nascimento, Tamires A. do | |
| Author | Almeida, Andresa K. A. de | |
| Author | Bombaça, Ana Cristina S. | |
| Author | Menna-Barreto, Rubem F. S. | |
| Author | Jacob, Claus | |
| Author | Warratz, Svenja | |
| Author | Silva Junior, Eufrânio N. da | |
| Author | Ackermann, Lutz | |
| Access date | 2019-09-17T13:31:51Z | |
| Available date | 2019-09-17T13:31:51Z | |
| Document date | 2019 | |
| Citation | DIAS, Gleiston G. et al. Ruthenium(II)-Catalyzed C–H Alkenylation of Quinones: Diversity-Oriented Strategy for Trypanocidal Compounds. European Journal of Organic Chemistry, v. 2019, n. 13, p. 2344–2353, 2019. | pt_BR |
| ISSN | 1099-0690 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/35630 | |
| Language | eng | pt_BR |
| Publisher | Wiley | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Catálise de rutênio (II) ativada | pt_BR |
| Subject in Portuguese | Compostos Tripanocidas | pt_BR |
| Subject in Portuguese | Quinones | pt_BR |
| Subject in Portuguese | Diversidade | pt_BR |
| Title | Ruthenium(II)-Catalyzed C–H Alkenylation of Quinones: Diversity-Oriented Strategy for Trypanocidal Compounds | pt_BR |
| Type | Article | |
| DOI | 10.1002/ejoc.201900004 | |
| Abstract | Ruthenium(II)-catalysis enabled C–H alkenylations of unactivated naphthoquinones for the preparation of A-ringmodified naphthoquinoidal compounds with activity against Trypanosoma cruzi, the parasite causing Chagas disease. The present study encompasses C–H alkenylation by weak O-coordi-nation by means of ruthenium(II) carboxylates. This method
provided an efficient and versatile tool towards a diversityoriented strategy for the preparation of compounds with a relevant biological profile. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Exatas. Departamento de Química. Belo Horizonte, MG, Brasil / Institut für Organische und Biomolekulare Chemie. Georg-August-Universität Göttingen. Göttingen, Germany. | pt_BR |
| Affilliation | Universidade Federal de Alagoas. Instituto de Química e Biotecnologia. Maceió, AL, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Alagoas. Instituto de Química e Biotecnologia. Maceió, AL, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Saarland University. School of Pharmacy. Division of Bioorganic Chemistry. Saarbrücken, Germany. | pt_BR |
| Affilliation | Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen. Göttingen, Germany. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Exatas. Departamento de Química. Belo Horizonte, MG, Brasil / Institut für Organische und Biomolekulare Chemie. Georg-August-Universität Göttingen. Göttingen, Germany. | pt_BR |
| Affilliation | Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen. Göttingen, Germany. | pt_BR |
| Subject | Ruthenium(II) | pt_BR |
| Subject | Trypanocidal Compounds | pt_BR |
| Subject | Quinones | pt_BR |
| Subject | Diversity-Oriented Strategy | pt_BR |
| Embargo date | 2022-01-01 | |
| xmlui.metadata.dc.subject.ods | 10 Redução das desigualdades | |
