Author | Chicaybam, Leonardo | |
Author | Bonamino, Martin Hernan | |
Access date | 2019-09-18T12:00:29Z | |
Available date | 2019-09-18T12:00:29Z | |
Document date | 2014 | |
Citation | CHICAYBAM, Leonardo; BONAMINO, Martin Hernan. Moving receptor redirected adoptive cell therapy toward fine tuning of antitumor responses. International Reviews of Immunology, p. 1-15, 2014. | pt_BR |
ISSN | 0883-0185 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/35649 | |
Language | eng | pt_BR |
Publisher | Informa Healthcare | pt_BR |
Rights | open access | pt_BR |
Title | Moving receptor redirected adoptive cell therapy toward fine tuning of antitumor responses | pt_BR |
Type | Article | pt_BR |
DOI | 10.3109/08830185.2014.917412 | |
Abstract | Adoptive cell transfer (ACT) is emerging as a powerful modality of cancer treatment. While ACT has proved able to induce massive clinical responses, genetic modification of T lymphocytes further improved clinical responses obtained. One of the major current limitations of ACT is the inability to discern healthy from malignant cells, leading to on target/off tumor responses that can limit its application. We here discuss some of the approaches currently under development and potential solutions to circumvent these limitations and extend this potentially curative therapy to different tumors by targeting a variety of antigens. | pt_BR |
Affilliation | Instituto Nacional de Câncer. Coordenação de Pesquisa. Programa de Carcinogênese Molecular. Rio de Janeiro, RJ, Brasil / Fundação Instituto Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Instituto Nacional de Câncer. Coordenação de Pesquisa. Programa de Carcinogênese Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Adoptive cell therapy | pt_BR |
Subject | Cancer | pt_BR |
Subject | Chimeric antigen receptor | pt_BR |
Subject | Gene therapy | pt_BR |
Subject | Immunotherapy | pt_BR |
Subject | Off-target | pt_BR |
Subject | Tumor antigen | pt_BR |
e-ISSN | 1563-5244 | |
Embargo date | 2020-09-18 | |