| Author | Morgan, Jess A. T. | |
| Author | Dejong, Randall J. | |
| Author | Adeoye, Grace O. | |
| Author | Ansa, Ebenezer D. O. | |
| Author | Barbosa, Constança S. | |
| Author | Brémond, Philippe | |
| Author | Cesari, Italo M. | |
| Author | Charbonnel, Nathalie | |
| Author | Corrêa, Lygia R. | |
| Author | Coulibaly, Godefroy | |
| Author | D'Andrea, Paulo Sérgio | |
| Author | Souza, Cecilia Pereira de | |
| Author | Doenhoff, Michael J. | |
| Author | File, Sharon | |
| Author | Idris, Mohamed A. | |
| Author | Incani, R. Nino | |
| Author | Jarne, Philippe | |
| Author | Karanja, Diana M. S. | |
| Author | Kazibwe, Francis | |
| Author | Kpikpi, John | |
| Author | Lwambo, Nicholas J. S. | |
| Author | Mabaye, Amadou | |
| Author | Magalhães, Luiz A. | |
| Author | Makundi, Asanteli | |
| Author | Moné, Hélène | |
| Author | Mouahid, Gabriel | |
| Author | Muchemi, Gerald M. | |
| Author | Mungai, Ben N. | |
| Author | Séne, Mariama | |
| Author | Southgate, Vaughan | |
| Author | Tchuenté, Louis Albert Tchuem | |
| Author | Théron, Andre | |
| Author | Yousif, Fouad | |
| Author | Magalhães, Eliana M. Zanotti | |
| Author | Mkoji, Gerald M. | |
| Author | Loker, Eric S. | |
| Access date | 2019-09-19T14:36:16Z | |
| Available date | 2019-09-19T14:36:16Z | |
| Document date | 2005 | |
| Citation | MORGAN, Jess A. T. et al. Origin and diversification of the human parasite Schistosoma mansoni. Molecular Ecology, v. 14, p. 3889-3902, 2005. | pt_BR |
| ISSN | 0962-1083 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/35687 | |
| Language | eng | pt_BR |
| Publisher | Wiley 12 Months | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | África | pt_BR |
| Subject in Portuguese | Biompjalaria | pt_BR |
| Subject in Portuguese | Brasil | pt_BR |
| Subject in Portuguese | Filogeografia | pt_BR |
| Subject in Portuguese | Esquistossomose | pt_BR |
| Subject in Portuguese | Tráfico de escravos | pt_BR |
| Title | Origin and diversification of the human parasite Schistosoma mansoni | pt_BR |
| Type | Article | |
| DOI | 10.1111/j.1365-294X.2005.02709.x | |
| Abstract | Schistosoma mansoni is the most widespread of the human-infecting schistosomes, present in 54 countries, predominantly in Africa, but also in Madagascar, the Arabian Peninsula, and the Neotropics. Adult-stage parasites that infect humans are also occasionally recovered from baboons, rodents, and other mammals. Larval stages of the parasite are dependent upon certain species of freshwater snails in the genus Biomphalaria, which largely determine the parasite's geographical range. How S. mansoni genetic diversity is distributed geographically and among isolates using different hosts has never been examined with DNA sequence data. Here we describe the global phylogeography of S. mansoni using more than 2500 bp of mitochondrial DNA (mtDNA) from 143 parasites collected in 53 geographically widespread localities. Considerable within-species mtDNA diversity was found, with 85 unique haplotypes grouping into five distinct lineages. Geographical separation, and not host use, appears to be the most important factor in the diversification of the parasite. East African specimens showed a remarkable amount of variation, comprising three clades and basal members of a fourth, strongly suggesting an East African origin for the parasite 0.30-0.43 million years ago, a time frame that follows the arrival of its snail host. Less but still substantial variation was found in the rest of Africa. A recent colonization of the New World is supported by finding only seven closely related New World haplotypes which have West African affinities. All Brazilian isolates have nearly identical mtDNA haplotypes, suggesting a founder effect from the establishment and spread of the parasite in this large country. | pt_BR |
| Affilliation | University of New Mexico. Department of Biology. Albuquerque, New Mexico, USA. | pt_BR |
| Affilliation | University of New Mexico. Department of Biology. Albuquerque, New Mexico, USA. | pt_BR |
| Affilliation | Univesity of Lagos. Department of Zoology. Akoka, Lagos, Nigeria. | pt_BR |
| Affilliation | CSIR Water Research Institute. Environmental Biology and Health Division. PO AH 38, Achimota, Accra, Ghana. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recife, PE, Brasil. | pt_BR |
| Affilliation | Equipe Schistosomoses, IRD, BP 434, 101 Antananarivo, Madagascar. | pt_BR |
| Affilliation | Instituto Venezolano de Investigaciones Científicas. Centro de Microbiología y Biología Celular. Caracas, Venezuela.. | pt_BR |
| Affilliation | Centre de Biologie et de Gestion des Populations. Campus International de Baillarguet, Montferrier s/Lez cedex. France. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Malacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Institut National de Recherche en Santé Publique. Bamako, Mali. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Medicina Tropical. Laboratório de Biologia e Controle da Esquistossomose. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | University of Wales. School of Biological Science. Bangor LL57 2UW, Gwynedd, Wales. | pt_BR |
| Affilliation | University of Puerto Rico. Department of Biology. San Juan, Puerto Rico. | pt_BR |
| Affilliation | Department of Microbiology and Immunology. College of Medicine and Health Sciences. Sultan Qaboos University. Muscat, Oman. | pt_BR |
| Affilliation | Universidad de Carabobo. Facultad de Ciencias de la Salud. Departamento de Parasitología. Valencia, Venezuela. | pt_BR |
| Affilliation | Centre d’Ecologie Fonctionelle et Evolutive–Centre National de la Recherche Scientifique. Montpellier Cedex 5, France. | pt_BR |
| Affilliation | Centre for Vector Biology and Control Research. Kenya Medical Research Institute. Kisumu, Kenya. | pt_BR |
| Affilliation | Ministry of Health. Department of Medical Entomology and Parasitology. Vector Control Division.Kampla, Uganda. | pt_BR |
| Affilliation | University of Ghana. Departmento of Zoology. Legon, Ghana. | pt_BR |
| Affilliation | National Institute for Medical Research. Mwanza, Tanzania. | pt_BR |
| Affilliation | Programme de Lutte Contre les Bilharzioses. Région Médicale de St Louis. St Louis, Senegal. | pt_BR |
| Affilliation | Universidade Estadual de Campinas. Instituto de Biologia. Departamento de Parasitología. Campinas, SP, Brasil. | pt_BR |
| Affilliation | Open University of Tanzania. Babati, Tanzania. | pt_BR |
| Affilliation | UMR 5555 CNRS-UP, CBETM. Université de Perpignan, 52 AV Paul Alduy, 66860 Perpignan cedex, France. | pt_BR |
| Affilliation | Department of Public Health. Pharmacology and Toxicology, University of Nairobi, PO Box 29053, Kabete, Kenya. | pt_BR |
| Affilliation | Centre for Biotechnology Research and Development. Kenya Medical Research Institut. Nairobi, Kenya. | pt_BR |
| Affilliation | Institut de Recherche pour le Développement (IRD). Laboratoire de Paludologie, B.P. 17688 Dakar-Liberté, Dakar, Senegal. | pt_BR |
| Affilliation | Department of Zoology. Biomedical Parasitology Division. Wolfson Wellcome Biomedical Laboratories. The Natural History Museum, Cromwell Road, South Kensington, London. | pt_BR |
| Affilliation | Center for Schistosomiasis and Parasitology, PO Box 7244, Yaoundé, Cameroon. | pt_BR |
| Affilliation | Schistosome Biological Supply Center, Theodor Bilharz Research Institute, PO Box 30 Imbaba, Egypt. | pt_BR |
| Subject | Africa | pt_BR |
| Subject | Biomphalaria | pt_BR |
| Subject | Brazil | pt_BR |
| Subject | Phylogeography | pt_BR |
| Subject | schistosomiasis | pt_BR |
| Subject | Slave trade | pt_BR |
| e-ISSN | 1365-294X | |
| Embargo date | 2025-01-01 | |
| xmlui.metadata.dc.subject.ods | 16 Paz, Justiça e Instituições Eficazes | |
