| Author | Rosado-de-Castro, Paulo Henrique | |
| Author | Schmidt, Felipe da Rocha | |
| Author | Battistella, Valeria | |
| Author | Souza, Sergio Augusto Lopes de | |
| Author | Gutfilen, Bianca | |
| Author | Goldenberg, Regina Coeli dos Santos | |
| Author | Kasai-Brunswick, Tais Hanae | |
| Author | Vairo, Leandro | |
| Author | Silva, Rafaella Monteiro | |
| Author | Wajnberg, Eduardo | |
| Author | Brasil, Pedro Emmanuel Alvarenga Americano do | |
| Author | Gasparetto, Emerson Leandro | |
| Author | Maiolino, Angelo | |
| Author | Alves-Leon, Soniza Vieira | |
| Author | Andre, Charles | |
| Author | Mendez-Otero, Rosalia | |
| Author | Freitas, Gabriel Rodriguez de | |
| Author | Fonseca, Lea Mirian Barbosa da | |
| Access date | 2019-09-26T14:18:33Z | |
| Available date | 2019-09-26T14:18:33Z | |
| Document date | 2013 | |
| Citation | ROSADO-DE-CASTRO, Paulo Henrique et al. Biodistribution of bone marrow mononuclear cells after intra-arterial or intravenous transplantation in subacute stroke patients. Regenerative Medicine, v. 8, n. 2, p. 145-155, 2013. | pt_BR |
| ISSN | 1746-0751 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/35924 | |
| Description | Pedro Emmanuel Americano Alvarenga do Brasil. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento. | pt_BR |
| Language | eng | pt_BR |
| Publisher | Future Medicine | pt_BR |
| Rights | restricted access | pt_BR |
| Title | Biodistribution of bone marrow mononuclear cells after intra-arterial or intravenous transplantation in subacute stroke patients | pt_BR |
| Type | Article | |
| DOI | 10.2217/rme.13.2 | |
| Abstract | Aims: To assess the biodistribution of bone marrow mononuclear cells (BMMNC) delivered by different routes in patients with subacute middle cerebral artery ischemic stroke. Patients & methods: This was a nonrandomized, open-label Phase I clinical trial. After bone marrow harvesting, BMMNCs were labeled
with technetium-99m and intra-arterially or intravenously delivered together with the unlabeled cells.
Scintigraphies were carried out at 2 and 24 h after cell transplantation. Clinical follow-up was continued for 6 months. Results: Twelve patients were included, between 19 and 89 days after stroke, and received 1–5 × 108
BMMNCs. The intra-arterial group had greater radioactive counts in the liver and spleen and lower counts in the lungs at 2 and 24 h, while in the brain they were low and similar for both routes. Conclusion: BMMNC labeling with technetium-99m allowed imaging for up to 24 h after intra-arterial or intravenous injection in stroke patients. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. School of Medicine. Department of Radiology. Rio de Janeiro, RJ, Brazil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Neurology Service. Rio de Janeiro, RJ, Brazil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Neurology Service. Rio de Janeiro, RJ, Brazil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. School of Medicine. Department of Radiology. Rio de Janeiro, RJ, Brazil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. School of Medicine. Department of Radiology. Rio de Janeiro, RJ, Brazil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Neurology Service. Rio de Janeiro, RJ, Brazil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. School of Medicine. Department of Radiology. Rio de Janeiro, RJ, Brazil. | pt_BR |
| Affilliation | D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. School of Medicine. Department of Radiology. Rio de Janeiro, RJ, Brazil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Hematology Service. Rio de Janeiro, RJ, Brazil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Neurology Service. Rio de Janeiro, RJ, Brazil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Neurology Service. Rio de Janeiro, RJ, Brazil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. School of Medicine. Department of Radiology. Rio de Janeiro, RJ, Brazil. | pt_BR |
| Subject | 99mTc | pt_BR |
| Subject | Bone marrow mononuclear cells | pt_BR |
| Subject | Cell transplatation | pt_BR |
| Subject | Cerebral infarct | pt_BR |
| Subject | Scinitigraphy | pt_BR |
| e-ISSN | 1746-076X | |
