| Author | Jesus, Talita dos Santos de | |
| Author | Costa, Ryan dos Santos | |
| Author | Neves, Neuza Maria Alcântara | |
| Author | Barreto, Maurício Lima | |
| Author | Figueiredo, Camila Alexandrina | |
| Access date | 2019-09-26T17:32:48Z | |
| Available date | 2019-09-26T17:32:48Z | |
| Document date | 2019 | |
| Citation | JESUS, Talita dos Santos de et al. Variants in the CYSLTR2 are associated with asthma, atopy markers and helminths infections in the Brazilian population. Prostaglandins, Leukotrienes and Essential Fatty Acids, v. 145, p. 15-22, 2019. | pt_BR |
| ISSN | 0952-3278 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/35942 | |
| Sponsorship | Coordenação de
Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) -
Finance Code 001. We thank all participants and all the collaborators of
the Laboratory Imunofarmacologia e Biologia Molecular for all support,
the Universidade Federal da Bahia for the structure to develop the work
and we thank Fapesb (Grant PNE0003/2014) and CNPq (Grant
133253/2017-1) for the support provided. | pt_BR |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | Asma | pt_BR |
| Subject in Portuguese | Atopia | pt_BR |
| Subject in Portuguese | Polimorfismo | pt_BR |
| Subject in Portuguese | CysLT | pt_BR |
| Title | Variants in the CYSLTR2 are associated with asthma, atopy markers and helminths infections in the Brazilian population | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.plefa.2019.05.003 | pt_BR |
| Abstract | Asthma is a chronic disease of the airways and its most common phenotype is characterized by a T2 type response with IgE production and inflammatory mediators in response to common allergens. Cysteinyl leukotrienes (CysLTs), LTC4, LTD4 and LTE4, are mediators known to possess important proinflammatory action. CysLTs can bind to the Cysteinyl leukotriene receptor type 2 (CysLTR2) and activate an inflammatory. Polymorphisms in CysLTR2 have been associated with asthma and atopy, although the mechanism is not clear. Objective: To evaluate the association between genetic polymorphisms in CYSLTR2 with asthma phenotypes,
atopy markers and helminth infection.
Methods: Genotyping was performed using a panel Illumina and carried out in 1245 participants of SCAALA
program (Social Change, Asthma, Allergy in Latin American). Logistic regressions for asthma, helminth infections
(Trichuris trichiura and Ascaris lumbricoides) and allergy markers (skin tests and IgE production) were
performed using PLINK 1.9 software adjusted for sex, age, helminth infection and ancestry markers.
Results: The G allele of rs1323556 was negatively associated with asthma in the additive model (OR 0.74, 95%
CI 0.59–0.93) and in the dominant model (OR 0.71, 95% CI 0.53–0.74). The G allele of rs1575464 was also
negatively associated with asthma in two genetic models, additive (OR 0.77, 95% CI 0.62–0.96) and dominant
(OR 0.73, 95% CI 0.55–0.97). The G allele of rs61735175 was positively associated with asthma severity in the
additive model (OR 1.72, 95% CI 1.07–2.77) and in the dominant model (OR 1.77, 95% CI 1.09–2.85). Five SNVs
were associated with atopy markers and four SNVs were associated with helminth infections.
Conclusion: Polymorphisms in the CYSLTR2 gene are associated with asthma, atopy markers and helminth infection
in Brazilian individuals, which may lead to protection or risk for such conditions, however, more studies
are needed to evaluate the functional of this variants here in described. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Laboratório de Imunofarmacologia e Biologia Molecular. Departamento de Biorregulação. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Laboratório de Imunofarmacologia e Biologia Molecular. Departamento de Biorregulação. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Laboratório de Imunofarmacologia e Biologia Molecular. Departamento de Biorregulação. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Laboratório de Imunofarmacologia e Biologia Molecular. Departamento de Biorregulação. Salvador, BA, Brasil. | pt_BR |
| Subject | Asthma | pt_BR |
| Subject | Atopy | pt_BR |
| Subject | Polymorphism | pt_BR |
| Subject | CysLT | pt_BR |
| e-ISSN | 10.1016/j.plefa.2019.05.003 | |
