| Author | Souza, Joelma Nascimento de | |
| Author | Soares, Barbara Nascimento Rocha Ribeiro | |
| Author | Goes, Luana Leandro | |
| Author | Lima, Cintia de Souza | |
| Author | Barreto, Nilo Manoel Pereira Vieira | |
| Author | Jacobina, Beatriz Soares | |
| Author | Gonçalves, Noilson | |
| Author | Teixeira, Marcia Cristina Aquino | |
| Author | Castro Filho, Bernardo Galvão | |
| Author | Grassi, Maria Fernanda Rios | |
| Author | Soares, Neci Matos | |
| Access date | 2019-09-26T18:13:23Z | |
| Available date | 2019-09-26T18:13:23Z | |
| Document date | 2018 | |
| Citation | SOUZA, Joelma Nascimento de et al. Case Report: Strongyloides stercoralis Hyperinfection in a Patient with HTLV-1: An Infection with Filariform and Rhabditiform Larvae, Eggs, and Free-Living Adult Females Output. American Journal of Tropical Medicine and Hygiene, v. 99, n. 6, p. 1583-1586, 2018. | pt_BR |
| ISSN | 0002-9637 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/35948 | |
| Sponsorship | Ministério da Saúde/Fundação de Amparo à Pesquisa do Estado da Bahia (PPSUS/FAPESB), Brazil. | pt_BR |
| Language | eng | pt_BR |
| Publisher | American Society of Tropical Medicine and Hygiene | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | Strongyloides stercoralis | pt_BR |
| Subject in Portuguese | Strongyloides | pt_BR |
| Subject in Portuguese | HTLV-I infecção | pt_BR |
| Subject in Portuguese | Vírus linfotrópico T humano 1 | pt_BR |
| Subject in Portuguese | Humanos | pt_BR |
| Title | Case Report: Strongyloides stercoralis Hyperinfection in a Patient with HTLV-1: An Infection with Filariform and Rhabditiform Larvae, Eggs, and Free-Living Adult Females Output | pt_BR |
| Type | Article | |
| DOI | 10.4269/ajtmh.18-0402 | |
| Abstract | Strongyloides stercoralis is the main etiological agent of human strongyloidiasis. Severe strongyloidiasis is commonly associated to alcoholism, corticostereoid use, and human T cell lymphotropic virus type 1 (HTLV-1) coinfection. Herein, we report a case of a 13-year-old boy coinfected with S. stercoralis and HTLV-1, excreting several parasitic forms in the stool. The parasitological examination of his feces showed a large amount of filariform (about 3,000 larvae per gram of feces) and rhabditiform larvae (about 2,000 larvae per gram of feces). In addition, free-living adult females (about 50 parasites per gram of feces) and eggs (about 60 eggs per gram of feces) were detected. The main laboratory findings pointed to high immunoglobulin E (IgE) levels (228 UI/mL) and eosinophila (11.6%). The patient was treated with three courses of ivermectin (200 µg/kg twice, 2 weeks apart), achieving the parasitological cure. An increase of about 19 times in interleucin (IL)-17 level was observed following the parasitological cure, in addition to a decrease in the white blood cell, eosinophil counts, and IgE levels. This is the first case report, to our knowledge, in which an S. stercoralis adult free-living female was described in human feces and where an increase in IL-17 levels after Strongyloides treatment in a HTLV-1 coinfected individual was observed. This finding raises the need for further studies about IL-17 immunomodulation in S. stercoralis and HTLV-1 coinfected patients. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Faculdade de Farmacia. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Faculdade de Farmacia. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Faculdade de Farmacia. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Escola Bahiana de Medicina e Saúde Pública. Centro Integrativo e Interdisciplinar de Centro Integrativo e Interdisciplinar para Atendimento de Portadores do Vírus Linfotrópico de Células T Humanas. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Escola Bahiana de Medicina e Saúde Pública. Centro Integrativo e Interdisciplinar de Centro Integrativo e Interdisciplinar para Atendimento de Portadores do Vírus Linfotrópico de Células T Humanas. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Faculdade de Farmacia. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Escola Bahiana de Medicina e Saúde Pública. Centro Integrativo e Interdisciplinar de Centro Integrativo e Interdisciplinar para Atendimento de Portadores do Vírus Linfotrópico de Células T Humanas. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Escola Bahiana de Medicina e Saúde Pública. Centro Integrativo e Interdisciplinar de Centro Integrativo e Interdisciplinar para Atendimento de Portadores do Vírus Linfotrópico de Células T Humanas. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Faculdade de Farmacia. Salvador, BA, Brasil. | pt_BR |
| Subject | Strongyloides stercoralis | pt_BR |
| Subject | Strongyloides | pt_BR |
| Subject | HTLV-I Infections | pt_BR |
| Subject | Human T-lymphotropic virus 1 | pt_BR |
| Subject | Humans | pt_BR |
| Embargo date | 2021-07-09 | |
