| Author | Oliveira-Filho, Edmilson Ferreira de | |
| Author | Santos, Debora R. l. dos | |
| Author | Durães-Carvalho, Ricardo | |
| Author | Silva, Adalúcia da | |
| Author | Lima, Gustavo Barbosa de | |
| Author | Batista Filho, Antônio Fernando B. | |
| Author | Pena, Lindomar J. | |
| Author | Gil, Laura H.V. G. | |
| Access date | 2019-09-27T13:48:14Z | |
| Available date | 2019-09-27T13:48:14Z | |
| Document date | 2019 | |
| Citation | OLIVEIRA-FILHO, Edmilson Ferreira de et al. Evolutionary study of potentially zoonotic hepatitis E virus genotype 3 from swine in Northeast Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 114, p. 1-5, 2019. | pt_BR |
| ISSN | 0074-0276 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/35956 | |
| Language | eng | pt_BR |
| Rights | open access | pt_BR |
| Title | Evolutionary study of potentially zoonotic hepatitis E virus genotype 3 from swine in Northeast Brazil | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1590/0074-02760180585 | |
| Abstract | Hepatitis E virus (HEV), an emerging virus associated with acute hepatic disease, leads to thousands of deaths worldwide. HEV has already been reported in Brazil; however, there is a lack of epidemiological and molecular information on the genetic variability, taxonomy, and evolution of HEV. It is thus unclear whether hepatitis E is a neglected disease in Brazil or it has low relevance for public health in this country. Here, for the first time, we report the presence of HEV in Northeast Brazil. A total of 119 swine faecal samples were screened for the presence of HEV RNA using real-time polymerase chain reaction (RT-PCR) and further confirmed by conventional RT-PCR; among these, two samples were identified as positive. Molecular evolution analyses based on capsid sequences revealed that the samples had close proximities to HEV sequences belonging to genotype 3 and were genetically related to subtype 3f isolated in humans. Parsimony ancestral states analysis indicated gene flow events from HEV cross-species infection, suggesting an important role of pig hosts in viral spillover. HEV's ability for zoonotic transmission by inter-species host switching as well as its possible adaptation to new animal species remain important issues for human health. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Virologia. Recife, PE, Brasil / Charité-Universitätsmedizin Berlin. Berlin Institute of Health. Institute of Virology. Berlin, Germany. | pt_BR |
| Affilliation | Universidade Federal Rural do Rio de Janeiro. Instituto de Veterinária. Seropédica, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Virologia. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Virologia. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Microbiologia. Recife, PE, Brasil. | pt_BR |
| Affilliation | Universidade Federal Rural de Pernambuco. Departamento de Medicina Veterinária. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Virologia. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Virologia. Recife, PE, Brasil. | pt_BR |
| Subject | Zoonotic hepatitis E virus | pt_BR |
| Subject | Swine | pt_BR |
| Subject | Genotype 3 | pt_BR |
| DeCS | Animais | pt_BR |
| DeCS | Brasil | pt_BR |
| DeCS | Capsídeo | pt_BR |
| DeCS | Virologia | pt_BR |
| DeCS | Fezes | pt_BR |
| DeCS | Genótipo | pt_BR |
| DeCS | Hepatite E | pt_BR |
| DeCS | Vírus da Hepatite E | pt_BR |
| DeCS | Genética | pt_BR |
| DeCS | Isolamento & purificação | pt_BR |
| DeCS | Humanos | pt_BR |
| DeCS | Filogenia | pt_BR |
| DeCS | RNA Viral | pt_BR |
| DeCS | Reação em Cadeia da Polimerase em Tempo Real | pt_BR |
| DeCS | Análise de Sequência de DNA | pt_BR |
| DeCS | Suínos | pt_BR |
| DeCS | Doenças dos Suínos | pt_BR |
| DeCS | Transmissão | pt_BR |
| DeCS | Zoonoses | pt_BR |
