| Author | Nonaka, Carolina Kymie Vasques | |
| Author | Macêdo, Carolina Thé | |
| Author | Cavalcante, Bruno Raphael Ribeiro | |
| Author | Alcântara, Adriano Costa de | |
| Author | Silva, Daniela Nascimento | |
| Author | Bezerra, Milena da Rocha | |
| Author | Caria, Alex Cleber Improta | |
| Author | Tavora, Fábio Rocha Fernandes | |
| Author | Souza Neto, João David de | |
| Author | Rabelo, Márcia Maria Noya | |
| Author | Rogatto, Silvia Regina | |
| Author | Santos, Ricardo Ribeiro dos | |
| Author | Souza, Bruno Solano de Freitas | |
| Author | Soares, Milena Botelho Pereira | |
| Access date | 2019-09-27T16:22:09Z | |
| Available date | 2019-09-27T16:22:09Z | |
| Document date | 2019 | |
| Citation | NONAKA, Carolina Kymie Vasques et al. Circulating miRNAs as Potential Biomarkers Associated with Cardiac Remodeling and Fibrosis in Chagas Disease Cardiomyopathy. International Journal of Molecular Sciences, v. 20, p. 1-16, 2019. | pt_BR |
| ISSN | 1661-6596 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/35972 | |
| Sponsorship | Bahia State Foundation for Research (FAPESB) and Institutos Nacionais de
Ciência e Tecnologia (INCT; 465656/2014-5). Milena B. P. Soares is a recipient of CNPq fellowship. | pt_BR |
| Language | eng | pt_BR |
| Publisher | MDPI | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Doença de Chagas | pt_BR |
| Subject in Portuguese | Cardiomiopatia | pt_BR |
| Subject in Portuguese | MicroRNA | pt_BR |
| Subject in Portuguese | Fibrose | pt_BR |
| Subject in Portuguese | Inflamação | pt_BR |
| Title | Circulating miRNAs as Potential Biomarkers Associated with Cardiac Remodeling and Fibrosis in Chagas Disease Cardiomyopathy | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.3390/ijms20164064 | |
| Abstract | Chagas disease (CD) affects approximately 6-7 million people worldwide, from which 30% develop chronic Chagas cardiomyopathy (CCC), usually after being asymptomatic for years. Currently available diagnostic methods are capable of adequately identifying infected patients, but do not provide information regarding the individual risk of developing the most severe form of the disease. The identification of biomarkers that predict the progression from asymptomatic or indeterminate form to CCC, may guide early implementation of pharmacological therapy. Here, six circulating microRNAs (miR-19a-3p, miR-21-5p, miR-29b-3p, miR-30a-5p, miR-199b-5p and miR-208a-3p) were evaluated and compared among patients with CCC (n = 28), CD indeterminate form (n = 10) and healthy controls (n = 10). MiR-19a-3p, miR-21-5p, and miR-29b-3p were differentially expressed in CCC patients when compared to indeterminate form, showing a positive correlation with cardiac dysfunction, functional class, and fibrosis, and a negative correlation with ejection fraction and left ventricular strain. Cardiac tissue analysis confirmed increased expression of microRNAs in CCC patients. In vitro studies using human cells indicated the involvement of these microRNAs in the processes of cardiac hypertrophy and fibrosis. Our study suggests that miRNAs are involved in the process of cardiac fibrosis and remodeling presented in CD and indicate a group of miRNAs as potential biomarkers of disease progression in CCC. | pt_BR |
| Affilliation | Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / São Rafael Hospital. Department of Cardiology. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil. | pt_BR |
| Affilliation | Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil. | pt_BR |
| Affilliation | Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Messejana Hospital. Fortaleza, CE, Brasil. | pt_BR |
| Affilliation | Messejana Hospital. Fortaleza, CE, Brasil. | pt_BR |
| Affilliation | São Rafael Hospital. Department of Cardiology. Salvador, BA, Brasil. | pt_BR |
| Affilliation | University of Southern Denmark. Institute of Regional Health Research. Vejle Hospital. Department of Clinical Genetics. Vejle, Denmark. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / National Institute of Science and Technology for Regenerative Medicine. Rio de Janeiro, RJ, Brazil. | pt_BR |
| Affilliation | Salvador, BA, Brasil / D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / National Institute of Science and Technology for Regenerative Medicine. Rio de Janeiro, RJ, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / National Institute of Science and Technology for Regenerative Medicine. Rio de Janeiro, RJ, Brazil. | pt_BR |
| Subject | Chagas disease | pt_BR |
| Subject | Cardiomyopathy | pt_BR |
| Subject | MicroRNA | pt_BR |
| Subject | Fibrosis | pt_BR |
| Subject | Inflammation | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
