Author | Paixão, Enny Santos da | |
Author | Campbell, Oona M. | |
Author | Teixeira, Maria Gloria | |
Author | Costa, Maria da Conceição Nascimento | |
Author | Harron, Katie | |
Author | Barreto, Mauricio Lima | |
Author | Leal, Maira Barreto | |
Author | Almeida, Marcia Furquim de | |
Author | Rodrigues, Laura Cunha | |
Access date | 2019-10-01T12:46:23Z | |
Available date | 2019-10-01T12:46:23Z | |
Document date | 2019 | |
Citation | PAIXÃO, Enny Santos da et al. Dengue during pregnancy and live birth outcomes: a cohort of linked data from Brazil. BMJ Open, v. 9, p. 1-8, 2019. | pt_BR |
ISSN | 2044-6055 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/36026 | |
Sponsorship | National Council for Scientific and Technological
Development (CNPq-Brazil); LR is partially funded by the European Union’s
Horizon 2020 research and innovation program under Zika-PLAN grant
agreement No. 734584; KH is funded by the Wellcome Trust (grant number
103975/Z/14/Z). | pt_BR |
Language | eng | pt_BR |
Publisher | BMJ Publishing Group | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Dengue | pt_BR |
Subject in Portuguese | Gravidez | pt_BR |
Subject in Portuguese | Nascidos vivos | pt_BR |
Subject in Portuguese | Estudos de Coortes | pt_BR |
Subject in Portuguese | Nascimento | pt_BR |
Subject in Portuguese | Brasil | pt_BR |
Title | Dengue during pregnancy and live birth outcomes: a cohort of linked data from Brazil | pt_BR |
Type | Article | pt_BR |
DOI | 10.1136/bmjopen-2018-023529 | |
Abstract | Dengue is the most common viral mosquito-borne disease, and women of reproductive age who live in or travel to endemic areas are at risk. Little is known about the effects of dengue during pregnancy on birth outcomes. The objective of this study is to examine the effect of maternal dengue severity on live birth outcomes. Design and setting We conducted a population-based cohort study using routinely collected Brazilian data from
2006 to 2012. Participating We linked birth registration records and
dengue registration records to identify women with and without dengue during pregnancy. Using multinomial logistic regression and Firth method, we estimated risk and ORs for preterm birth (<37 weeks’ gestation), low
birth weight (<2500 g) and small for gestational age (<10thcentile). We also investigated the effect of time between the onset of the disease and each outcome. Results We included 16 738 000 live births. Dengue
haemorrhagic fever was associated with preterm birth (OR=2.4; 95% CI 1.3 to 4.4) and low birth weight (OR=2.1; 95% CI 1.1 to 4.0), but there was no evidence of effect for small for gestational age (OR=2.1; 95% CI 0.4 to 12.2). The magnitude of the effects was higher in the acute disease
period. Conclusion This study showed an increased risk of adverse birth outcomes in women with severe dengue during pregnancy. Medical intervention to mitigate maternal risk during severe acute dengue episodes may improve outcomes for infants born to exposed mothers. | pt_BR |
Affilliation | London School of Hygiene & Tropical Medicine. Faculty of Epidemiology and Population Health. London, UK. | pt_BR |
Affilliation | London School of Hygiene & Tropical Medicine. Faculty of Epidemiology and Population Health. London, UK. | pt_BR |
Affilliation | Federal University of Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brazil. | pt_BR |
Affilliation | Federal University of Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brazil. | pt_BR |
Affilliation | London School of Hygiene & Tropical Medicine. Department of Health Services Research and Policy. London, UK. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil / Universidade Federal da Bahia, Instituto de Matemática. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil. | pt_BR |
Affilliation | Federal University of Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brazil. | pt_BR |
Affilliation | Universidade de São Paulo. School of Public Health. São Paulo, SP, Brasil. | pt_BR |
Affilliation | London School of Hygiene & Tropical Medicine. Faculty of Epidemiology and Population Health. London, UK. | pt_BR |
Subject | Dengue | pt_BR |
Subject | Pregnancy | pt_BR |
Subject | Live Birth | pt_BR |
Subject | Cohort Studies | pt_BR |
Subject | Parturition | pt_BR |
Subject | Brazil | pt_BR |
e-ISSN | 2044-6055 | |