| Author | Mas-Sandoval, Alex | |
| Author | Arauna, Lara R. | |
| Author | Gouveia, Mateus Henrique | |
| Author | Barreto, Mauricio Lima | |
| Author | Horta, Bernardo Lessa | |
| Author | Costa, Maria Fernanda Lima | |
| Author | Pereira, Alexandre da Costa | |
| Author | Salzano, Francisco M. | |
| Author | Hünemeier, Tábita | |
| Author | Santos, Eduardo Tarazona | |
| Author | Bortolini, Maria Cátira | |
| Author | Comas, David | |
| Access date | 2019-10-08T16:52:06Z | |
| Available date | 2019-10-08T16:52:06Z | |
| Document date | 2019 | |
| Citation | MAS-SANDOVAL, Alex et al. Reconstructed Lost Native American Populations from Eastern Brazil Are Shaped by Differential Jê/Tupi Ancestry. Genome Biology and Evolution, v. 11, n. 9, p. 2593-2604, 2019. | pt_BR |
| ISSN | 1759-6653 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/36280 | |
| Sponsorship | Spanish Ministerio de
Economia y Competitividad - Programa CSIC de cooperaci on
cient ıfica para el desarrollo (COOP20099), the Agencia Estatal
de Investigaci on and Fondo Europeo de Desarollo Regional
(FEDER) grant CGL2016-75389-P, the “Unidad de Excelencia
Maria de Maeztu” MDM2014-0370, and Secretaria
d’Universitats i Recerca del Departament d’Economia i
Coneixement de la Generalitat de Catalunya (GRC 2017
SGR 00702). This study was financed in part by the
Coordenac¸~ao de Aperfeic¸oamento de Pessoal de N ıvel
Superior—Brasil (CAPES)—Finance Code 001. The EPÌGEN Brazil Initiative was funded by the Brazilian Ministry of
Health (Department of Science and Technology from the
Secretaria de Ci^encia, Tecnologia e Insumos Estrat egicos)
through Financiadora de Estudos e Projetos. | pt_BR |
| Language | eng | pt_BR |
| Publisher | Oxford University Press | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Diversidade do genoma humano | pt_BR |
| Subject in Portuguese | Grupos indígenas americanos | pt_BR |
| Subject in Portuguese | Brasil | pt_BR |
| Title | Reconstructed Lost Native American Populations from Eastern Brazil Are Shaped by Differential Jê/Tupi Ancestry | pt_BR |
| Type | Article | |
| DOI | 10.1093/gbe/evz161 | pt_BR |
| Abstract | After the colonization of the Americas by Europeans and the consequent Trans-Atlantic Slave Trade, most Native American populations in eastern Brazil disappeared or went through an admixture process that configured a population composed of three main genetic components: the European, the sub-Saharan African, and the Native American. The study of the Native American genetic history is challenged by the lack of availability of genome-wide samples from Native American populations, the technical difficulties to develop ancient DNA studies, and the low proportions of the Native American component in the admixed Brazilian populations (on average 7%). We analyzed genome-wide data of 5,825 individuals from three locations of eastern Brazil: Salvador (North-East), Bambui (South-East), and Pelotas (South) and we reconstructed populations that emulate the Native American groups that were living in the 16th century around the sampling locations. This genetic reconstruction was performed after local ancestry analysis of the admixed Brazilian populations, through the rearrangement of the Native American haplotypes into reconstructed individuals with full Native American ancestry (51 reconstructed individuals in Salvador, 45 in Bambui, and 197 in Pelotas). We compared the reconstructed populations with nonadmixed Native American populations from other regions of Brazil through haplotype-based methods. Our results reveal a population structure shaped by the dichotomy of Tupi-/Jê-speaking ancestry related groups. We also show evidence of a decrease of the diversity of nonadmixed Native American groups after the European contact, in contrast with the reconstructed populations, suggesting a reservoir of the Native American genetic diversity within the admixed Brazilian population. | pt_BR |
| Affilliation | Universidade Federal do Rio Grande do Sul. Instituto de Biociências. Departamento de Genética. Porto Alegre, RS, Brazil / Universitat Pompeu Fabra. Institute of Evolutionary Biology. Departament de Ciències Experimentals i de la Salut. Barcelona, Spain. | pt_BR |
| Affilliation | Universitat Pompeu Fabra. Institute of Evolutionary Biology. Departament de Ciències Experimentals i de la Salut. Barcelona, Spain. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Biologia Geral. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Programa de Universidade Federal de Pelotas. Pós-Graduação em Epidemiologia. Pelotas, RS, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Rene Rachou. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Universidade de São Paulo. Instituto do Coração. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio Grande do Sul. Instituto de Biociências. Departamento de Genética. Porto Alegre, RS, Brazil | pt_BR |
| Affilliation | University of São Paulo. Department of Genetics and Evolutionary Biology, Biosciences Institute. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Biologia Geral. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Universidade Federal do Rio Grande do Sul. Instituto de Biociências. Departamento de Genética. Porto Alegre, RS, Brazil / Universitat Pompeu Fabra. Institute of Evolutionary Biology. Departament de Ciències Experimentals i de la Salut. Barcelona, Spain. | pt_BR |
| Affilliation | Universitat Pompeu Fabra. Institute of Evolutionary Biology. Departament de Ciències Experimentals i de la Salut. Barcelona, Spain. | pt_BR |
| Subject | Human genome diversity | pt_BR |
| Subject | Native American groups | pt_BR |
| Subject | Brazil | pt_BR |
| xmlui.metadata.dc.subject.ods | 10 Redução das desigualdades | |
| xmlui.metadata.dc.subject.ods | 16 Paz, Justiça e Instituições Eficazes | |
