| Author | Nicol, A. F. | pt_BR |
| Author | Nuovo, G. J. | pt_BR |
| Author | Wang, Y. | pt_BR |
| Author | Grinsztejn, Beatriz | pt_BR |
| Author | Tristão, A. | pt_BR |
| Author | Russomano, Fábio Bastos | pt_BR |
| Author | Perez, M. A. | pt_BR |
| Author | Silva, J. R. Lapa | pt_BR |
| Author | Fernandes, A. T. G. | pt_BR |
| Author | Gage, J. R. | pt_BR |
| Author | Martínez-Maza, O. | pt_BR |
| Author | Almeida, Maria da Glória Bonecini de | pt_BR |
| Access date | 2010-08-23T16:00:29Z | |
| Available date | 2010-08-23T16:00:29Z | |
| Document date | 2006 | |
| Citation | NICOL, A. F. et al. In situ detection of SOCS and cytokine expression in the uterine cervix from HIV/HPV coinfected women. Exp. Mol. Pathol, New York, v. 81, n. 1, p. 42-47, 2006. | pt_BR |
| ISSN | 0014-4800 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/363 | |
| Language | eng | pt_BR |
| Publisher | S. Farger | |
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| Rights | restricted access | |
| Title | In situ detection of SOCS and cytokine expression in the uterine cervix from HIV/HPV coinfected women | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.yexmp.2006.01.002 | |
| Abstract | The purpose of this study was to look for associations between a newly described class of suppressors of cytokine signaling (SSI/SOCS) andcytokine expression in the uterine cervix from HIV/HPV coinfected women. We examined the pro-inflammatory cytokines TNF-α and IL-6 since their expressions are linked and responsible for many aspects of both localized and systemic inflammatory responses. Further, expression of SSI/SOCS has been implicated in the negative feedback regulation of cytokine receptor signaling. PCR-amplified HIV-1 cDNA was noted mainly in the stroma, showing a perivascular distribution, and most of the infected cells colabeled with the macrophage marker CD68. The distribution of IL-6 and TNF-α was in the same area to HIV-1 and much greater than normal cervices from women with no evidence of viral infection. SOCS/SSI-1 and -3 mRNA positive cells in the uterine cervix were commonly detected in these noninfected cervical tissues; however, very few cells that contained SOCS were evident in areas where HIV-1, TNF-α, and IL-6 expressing cells were found. This suggests that viral-related suppression of SOCS/SSI-1-3 expression may be a factor in the marked local enhancement of TNF-α and IL-6 production which, in turn, may help facilitate viral spread; however, further studies should be done in order to elucidate the exact mechanisms of SOCS in the cervix. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Evandro Chagas. Serviços de Imunologia. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | University Hospitals. Department of Pathology. Columbus, OH, USA. | |
| Affilliation | University Hospitals. Department of Pathology. Columbus, OH, USA. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Evandro Chagas. Departamento de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Evandro Chagas. Departamento de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Laboratório Multidisciplinar. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Evandro Chagas. Serviços de Imunologia. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | David Geffen School of Medicine. Departments of Obstetrics and Gynecology and Microbiology, Immunology and Molecular Genetics. Los Angeles, CA, USA. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Evandro Chagas. Serviços de Imunologia. Rio de Janeiro, RJ, Brasil. | |
| Subject | SSI-SOCS | |
| Subject | Uterine Cervix | |
| Subject | In Situ RT-PCR | |
| Subject | HIV-1/HPV Coinfection | |
| DeCS | Proteínas Supressoras da Sinalização de Citocina | |
| DeCS | Colo do Útero | |
| DeCS | HIV-1 | |
| DeCS | Sondas de DNA de HPV | |
