| Author | Nosanchuk, Joshua D. | |
| Author | Zancopé-Oliveira, Rosely M. | |
| Author | Hamilton, Andrew J. | |
| Author | Guimarães, Allan J. | |
| Access date | 2019-10-17T12:53:58Z | |
| Available date | 2019-10-17T12:53:58Z | |
| Document date | 2012 | |
| Citation | NOSANCHUK, Joshua D. et al. Antibody therapy for histoplasmosis. Frontiers in Microbiology, v. 3, n. 21, p. 1-7, Feb. 2012. | pt_BR |
| ISSN | 1664-302X | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/36512 | |
| Language | eng | pt_BR |
| Publisher | Frontiers Media | pt_BR |
| Rights | open access | pt_BR |
| Title | Antibody therapy for histoplasmosis | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.3389/fmicb.2012.00021 | |
| Abstract | The endemic human pathogenic fungus Histoplasma capsulatum is a major fungal pathogen with a broad variety of clinical presentations, ranging from mild, focal pulmonary disease to life-threatening systemic infections. Although azoles, such as itraconazole and voriconazole, and amphotericin B have significant activity against H. capsulatum, about 1 in 10 patients hospitalized due to histoplasmosis die. Hence, new approaches for managing disease are being sought. Over the past 10 years, studies have demonstrated that monoclonal antibodies (mAbs) can modify the pathogenesis of histoplasmosis. Disease has been shown to be impacted by mAbs targeting either fungal cell surface proteins or host co-stimulatory molecules. This review will detail our current knowledge regarding the impact of antibody therapy on histoplasmosis. | pt_BR |
| Affilliation | Albert Einstein College of Medicine. Department of Medicine. New York, NY, USA / Albert Einstein College of Medicine. Department of Microbiology and Immunology. New York, NY, USA. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Micologia. Setor de Imunodiagnóstico. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Kings College. Guys Hospital. Dermatology Laboratory. London, UK. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Professor Paulo de Góes. Departmento de Imunologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Histoplasma capsulatum | pt_BR |
| Subject | Histoplasmosis | pt_BR |
| Subject | Antibody | pt_BR |
| Subject | Histone 2B | pt_BR |
| Subject | Heat shock protein 60 | pt_BR |
| Subject | M antigen | pt_BR |
| Subject | Co-stimulation | pt_BR |
| e-ISSN | 1664-302X | |
