| Author | Gomes, Paulo André Teixeira de Moraes | |
| Author | Pena, Lindomar J. | |
| Author | Leite, Ana C. Lima | |
| Access date | 2019-10-17T13:23:55Z | |
| Available date | 2019-10-17T13:23:55Z | |
| Document date | 2019 | |
| Citation | GOMES, Paulo André Teixeira de Moraes; PENA, Lindomar J.; LEITE, Ana C. Lima. Isatin Derivatives and Their Antiviral Properties Against Arboviruses: A Review. Mini Reviews in Medicinal Chemistry, v. 19, n. 1, p. 56–62, 2019. | pt_BR |
| ISSN | 1389-5575 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/36515 | |
| Language | eng | pt_BR |
| Rights | restricted access | pt_BR |
| Title | Isatin Derivatives and Their Antiviral Properties Against Arboviruses: A Review | pt_BR |
| Type | Article | |
| DOI | 10.2174/1389557518666180424093305 | |
| Abstract | Arboviruses have been spreading rapidly throughout the Western Hemisphere in recent decades. Among the arboviruses with high morbidity and mortality are the members of the Alphavirus and Flavivirus genera. Within the first genus, Chikungunya Virus (CHIKV) is considered one of the most challenging human arboviral infection worldwide, against which there is no specific antivirals. Flaviviruses are some of the main viruses responsible for encephalitis, haemorrhagic disease and developmental defects. Dengue virus (DENV), Japanese Encephalitis Virus (JEV), West Nile Virus (WNV) and Zika Virus (ZIKV) are examples of flaviviruses without clinically approved antiviral agents. Thus, the search for new antivirals becomes highly important. One of the strategies that can be employed to obtain new drugs is the identification and utilization of privileged structures. Isatin is an example of a privileged molecular framework, displaying a broad spectrum of biological activities, including antiviral action. Obtaining and studying the antiviral properties of isatin derivatives have helped to identify important agents with potential activity against different arboviruses. This article reviews some of these isatin derivatives, their structures and antiviral properties reported against this important group of viruses. | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Laboratório de Planejamento de Química Medicinal Departamento de Ciências Farmacêuticas. Recife, PE, Brasil / Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Virologia e Terapia Experimental. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Virologia e Terapia Experimental. Recife, PE, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Laboratório de Planejamento de Química Medicinal. Departamento de Ciências Farmacêuticas. Recife, PE, Brasil. | pt_BR |
| Subject | Arbovirus | pt_BR |
| Subject | Chikungunya virus | pt_BR |
| Subject | Dengue virus | pt_BR |
| Subject | Isatin | pt_BR |
| Subject | Japanese encephalitis virus | pt_BR |
| Subject | West Nile virus | pt_BR |
| Subject | Zika virus | pt_BR |
| DeCS | Animais | pt_BR |
| DeCS | Antivirais / química | pt_BR |
| DeCS | Antivirais / farmacologia | pt_BR |
| DeCS | Antivirais / uso terapêutico | pt_BR |
| DeCS | Infecções por Arbovirus / tratamento farmacológico | pt_BR |
| DeCS | Arbovirus / efeitos dos fármacos | pt_BR |
| DeCS | Descoberta de Drogas / métodos | pt_BR |
| DeCS | Humanos | pt_BR |
| DeCS | Isatina / chemistry | pt_BR |
| DeCS | Isatina / farmacologia | pt_BR |
| DeCS | Isatina / uso terapêutico | pt_BR |
| Embargo date | 2050-01-01 | |
