| Author | Cosenza, Gustavo Pereira | |
| Author | Viana, Celso T.R. | |
| Author | Campos, Paula P. | |
| Author | Kohlhoff, Markus | |
| Author | Fagg, Christopher Williama | |
| Author | Brandão, Maria das Graças Lins | |
| Access date | 2019-10-17T13:46:39Z | |
| Available date | 2019-10-17T13:46:39Z | |
| Document date | 2019 | |
| Citation | COSENZA, Gustavo Pereira et al. Chemical characterization, antihyperlipidaemic and antihyperglycemic effects of Brazilian bitter quina species in mice consuming a high-refined carbohydrate diet. Journal of Functional Foods, v. 54, p. 220-230, 2019. | pt_BR |
| ISSN | 1756-4646 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/36520 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | pt_BR |
| Title | Chemical characterization, antihyperlipidaemic and antihyperglycemic effects of Brazilian bitter quina species in mice consuming a high-refined carbohydrate diet | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.jff.2019.01.030 | |
| Abstract | Quina is the popular name for species of Cinchona, native to Peru and whose barks produce quinine. Currently, quinine is also used as a bitter additive in tonic water and drinks. Cinchona species do not occur in Brazil, but other species are known as quina, due their bitter taste and use as digestive tonics. In this study, six species of Brazilian quina were chemically characterized and three of them evaluated as antihyperlipidaemic and antihyperglycemic agents. The chemical composition was determined by spectroscopy, HPLC-DAD and LC-MS. Plasma concentrations of glucose and cholesterol were strongly reduced in animals receiving extracts from Baccharis trimera and Strychnos pseudoquina. These effects were attributed to the presence of higher concentrations of flavonoids and organic acids. S. pseudoquina also promoted a significant reduction of triglyceride, as well as a better fat distribution. The cytotoxicity assay the R. ferruginea and S. pseudoqina species in LD50 are greater than 1000 μg/mL and a percent viability during the 100% assay. B. trimera has already been applied to DL50 with a very high dose of 4.92 μg/mL, presenting a low viability during the analysis and cytotoxic assimilation. The results of this study confirm the role of bitter quina in digestive metabolic disorders. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Museu de História Natural e Jardim Botânico. CEPLAMT. Belo Horizonte, MG, Brasil / Universidade Federal de Minas Gerais. Programa de Pós-Graduação em Ciências de Alimentos. Faculdade de Farmácia. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Patologia Geral. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Patologia Geral. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Química de Produtos Naturais Bioativos. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Universidade de Brasilia. Departamento de Botânica. Brasilia, DF, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Museu de História Natural e Jardim Botânico. CEPLAMT. Belo Horizonte, MG, Brasil / Universidade Federal de Minas Gerais. Programa de Pós-Graduação em Ciências de Alimentos. Faculdade de Farmácia. Belo Horizonte, MG, Brasil. | pt_BR |
| Subject | Quina | pt_BR |
| Subject | Quinine | pt_BR |
| Subject | Cholesterol | pt_BR |
| Subject | Glucose | pt_BR |
| Subject | Digestive metabolic disorders | pt_BR |
| Embargo date | 2035-01-01 | |
