| Autor | Cerbino-Neto, José | |
| Autor | Santos, Ananza Tainá da Silva | |
| Autor | Gouvea, Maria Isabel Fragoso da Silveira | |
| Autor | Pedro, Renata Saraiva | |
| Autor | Ramos, Grazielle Viana | |
| Autor | Guaraldo, Lusiele | |
| Autor | Werneck, Guilherme Loureiro | |
| Data de acesso | 2019-10-21T14:57:33Z | |
| Data de disponibilização | 2019-10-21T14:57:33Z | |
| Data do publicação | 2012 | |
| Citação | CERBINO-NETO, José et al. Comparison of adverse events following immunization with pandemic influenza A (H1N1)pdm09 vaccine with or without adjuvant among health professionals in Rio de Janeiro, Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 107, n. 7, p. 923-927, Nov. 2012. | pt_BR |
| ISSN | 0074-0276 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/36604 | |
| Idioma | eng | pt_BR |
| Editor | Fiocruz/IOC | pt_BR |
| Direito Autoral | open access | pt_BR |
| Título | Comparison of adverse events following immunization with pandemic influenza A (H1N1)pdm09 vaccine with or without adjuvant among health professionals in Rio de Janeiro, Brazil | pt_BR |
| Tipo do documento | Article | pt_BR |
| DOI | 10.1590/S0074-02762012000700014 | |
| Resumo em Inglês | A vaccination campaign against pandemic influenza A (H1N1)pdm09 was held in Brazil in March 2010, using
two types of monovalent split virus vaccines: an AS03-adjuvanted vaccine and a non-adjuvanted vaccine. We compared the reactogenicity of the vaccines in health professionals from a Clinical Research Institute in Rio de Janeiro, Brazil and there were no serious adverse events following immunization (AEFI) among the 494 subjects evaluated. The prevalence of any AEFI was higher in the AS03-adjuvanted vaccine at 2 h and 24 h post-vaccination [prevalence ratio (PR): 2.05, confidence interval (CI) 95%: 1.55-2.71, PR: 3.42, CI 95%: 2.62-4.48, respectively]; however, there was no difference between the vaccines in the assessments conducted at seven and 21 days post-vaccination. The group receiving the AS03 post-adjuvanted vaccine had a higher frequency of local reactions at 2 h (PR: 3.01, CI 95%: 2.12-4.29), 24 h (PR: 4.57, CI 95%: 3.29-6.37) and seven days (PR: 6.05, CI 95%: 2.98-12.28) post-vaccination. We concluded that the two types of vaccines caused no serious AEFI in the studied population and the adjuvanted vaccine was more reactogenic, particularly in the 24 h following vaccination. This behaviour must be confirmed and better characterised by longitudinal studies in the general population. | pt_BR |
| Afiliação | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Afiliação | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Afiliação | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Afiliação | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Afiliação | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Afiliação | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Afiliação | Universidade do Estado do Rio de Janeiro. Instituto de Medicina Social. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Palavras-chave em inglês | Influenza A virus | pt_BR |
| Palavras-chave em inglês | H1N1 subtype | pt_BR |
| Palavras-chave em inglês | Influenza vaccines | pt_BR |
| Palavras-chave em inglês | Adverse effects | pt_BR |
| e-ISSN | 1678-8060 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
