| Author | Alves, A. S. | |
| Author | Mouta-Confort, E. | |
| Author | Figueiredo, F. B. | |
| Author | Oliveira, R. V. | |
| Author | Schubach, A. O. | |
| Author | Madeira, M. F. | |
| Access date | 2019-10-29T12:41:59Z | |
| Available date | 2019-10-29T12:41:59Z | |
| Document date | 2012 | |
| Citation | ALVES, A. S. et al. Evaluation of serological cross-reactivity between canine visceral leishmaniasis and natural infection byTrypanosoma caninum. Research in Veterinary Science, v. 93, p. 1329-1333, 2012. | pt_BR |
| ISSN | 0034-5288 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/36730 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | open access | pt_BR |
| Title | Evaluation of serological cross-reactivity between canine visceral leishmaniasis and natural infection by Trypanosoma caninum | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1016/j.rvsc.2012.07.006 | |
| Abstract | In order to evaluate if the presence of Trypanosoma caninum can lead to a confuse diagnosis of canine visceral leishmaniasis (CVL), we investigated the serological status of dogs infected by T. caninum and assessed the serological cross-reactivity with CVL. A set of 117 serum samples from dogs infected by T. caninum, Leishmania chagasi and not infected dogs (n = 39 in each group) was tested using commercial kits – indirect immunofluorescence (IFI-LVC), ELISA (EIE-LVC) and immunochromatographic test (DPP) – and in house tests with T. caninum (IIF-Tc and ELISA-Tc) and L. chagasi antigens (IIF-Lc and ELISA-Lc). IIF-Tc and ELISA-Tc presented sensitivity of 64.1% and 94.9% and specificity of 23.1% and 35.9%, respectively. The sensitivity of the IFI-LVC, EIE-LVC and DPP tests was 100% and the specificity was 70.5%, 68% and 97.5% respectively. The concordance between the tests was considered as satisfactory. The specificities of IFI-LVC, EIE-LVC and DPP were higher when the group Tc was excluded, with significant values for IFI-LVC (χ2 = 4.36, P-value = 0.036), thus suggesting that the infection by T. caninum can confuse the diagnosis of CVL. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Programa de pós-graduação em Pesquisa Clínica em Doenças Infecciosas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatozoonoses de Animais Domésticos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Epidemiologia Clínica. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Leishmania chagasi | pt_BR |
| Subject | Trypanosoma caninum | pt_BR |
| Subject | Diagnosis | pt_BR |
| Subject | Cross reaction | pt_BR |
| Subject | Dogs | pt_BR |
| e-ISSN | 1532-2661 | |
| Embargo date | 2020-10-29 | |
