Author | Sá, Ricardo Tristão | |
Author | Kubelka, Claire Fernandes | |
Author | Zandonade, Eliana | |
Author | Zagne, Sônia Maria Oliveira | |
Author | Rocha, Natally de Souza Maciel | |
Author | Zagne, Luiza Oliveira | |
Author | Araújo, Nathália Félix | |
Author | Amin, Beatriz | |
Author | Fazoli, Flávia | |
Author | Souza, Luiz José de | |
Author | Cruz, Oswaldo Gonçalves | |
Author | Cunha, Rivaldo Venâncio da | |
Author | Nascimento, Delso do | |
Author | Froes, Iris Bucher | |
Author | Nogueira, Rita Maria Ribeiro | |
Access date | 2019-10-29T13:24:04Z | |
Available date | 2019-10-29T13:24:04Z | |
Document date | 2012 | |
Citation | SÁ, Ricardo Tristão et al. Clinical and hepatic evaluation in adult dengue patients: a prospective two-month cohort study. Revista da Sociedade Brasileira de Medicina Tropical, v. 45, n. 6, p. 675-681, Nov./Dec. 2012. | pt_BR |
ISSN | 0037-8682 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/36736 | |
Language | eng | pt_BR |
Publisher | Sociedade Brasileira de Medicina Tropical | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Dengue | pt_BR |
Subject in Portuguese | Disfunção hepática | pt_BR |
Subject in Portuguese | Persistência dos sintomas | pt_BR |
Subject in Portuguese | Coorte em perspectiva | pt_BR |
Title | Clinical and hepatic evaluation in adult dengue patients: a prospective two-month cohort study | pt_BR |
Type | Article | pt_BR |
DOI | 10.1590/s0037-86822012000600004 | |
Abstract | Introduction: To analyze the liver dysfunction and evolution of signs and symptoms in adult dengue patients during a two-month follow-up period. Methods: A prospective cohort study was conducted in Campos dos Goytacazes, Rio de Janeiro, Brazil, from January to July, 2008. The evolution of laboratory and clinical manifestations of 90 adult dengue patients was evaluated in five scheduled visits within a two-month follow-up period. Twenty controls were enrolled for the analysis of liver function. Patients with hepatitis B, hepatitis C, those known to be human immunodeficiency virus (HIV) seropositive and pregnant women were excluded from the study. Results: At the end of the second month following diagnosis, we observed that symptoms persisted in 33.3% (30/90) of dengue patients. We also observed that, 57.7% (15/26) of the symptoms persisted at the end of the second month. The most persistent symptoms were arthralgia, fatigue, weakness, adynamia, anorexia, taste alteration, and hair loss. Prior dengue virus (DENV) infection did not predispose patients to a longer duration of symptoms. Among hepatic functions, transaminases had the most remarkable elevation and in some cases remained elevated up to the second
month after the disease onset. Alanine aminotransferase (ALT) levels overcame aspartate aminotransferase (AST) during the convalescent period. Male patients were more severely affected than females. Conclusions: Dengue fever may present a wide number of symptoms and elevated liver transaminases at the end of the second month. | pt_BR |
Affilliation | Santa Casa de Misericórdia de Vitória. Escola Superior de Ciências. Departamento de Clínica Médica. Vitória, ES, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Espírito Santo. Programa de Pós Graduação em Saúde Coletiva. Vitória, ES, Brasil. | pt_BR |
Affilliation | Universidade Federal Fluminense. Departamento de Clínica Médica. Niterói, RJ, Brasil. | pt_BR |
Affilliation | Centro de Referência de Dengue de Campos dos Goytacazes. Campos dos Goytacazes, RJ, Brasil. | pt_BR |
Affilliation | Centro de Referência de Dengue de Campos dos Goytacazes. Campos dos Goytacazes, RJ, Brasil. | pt_BR |
Affilliation | Centro de Referência de Dengue de Campos dos Goytacazes. Campos dos Goytacazes, RJ, Brasil. | pt_BR |
Affilliation | Centro de Referência de Dengue de Campos dos Goytacazes. Campos dos Goytacazes, RJ, Brasil. | pt_BR |
Affilliation | Centro de Referência de Dengue de Campos dos Goytacazes. Campos dos Goytacazes, RJ, Brasil. | pt_BR |
Affilliation | Centro de Referência de Dengue de Campos dos Goytacazes. Campos dos Goytacazes, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Presidência. Programa de Computação Científica. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Mato Grosso do Sul. Departamento de Clínica Médica. Campo Grande, MS, Brasil. | pt_BR |
Affilliation | Universidade Federal do Mato Grosso do Sul. Departamento de Clínica Médica. Campo Grande, MS, Brasil. | pt_BR |
Affilliation | Universidade Federal do Mato Grosso do Sul. Departamento de Clínica Médica. Campo Grande, MS, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Dengue | pt_BR |
Subject | Hepatic dysfunction | pt_BR |
Subject | Persistence of symptoms | pt_BR |
Subject | Prospective cohort | pt_BR |
e-ISSN | 1678-9849 | |