| Author | Grinsztejn, Beatriz | |
| Author | Hughes, Michael D. | |
| Author | Ritz, Justin | |
| Author | Salata, Robert | |
| Author | Mugyenyi, Peter | |
| Author | Hogg, Evelyn | |
| Author | Wieclaw, Linda | |
| Author | Gross, Robert | |
| Author | Godfrey, Catherine | |
| Author | Cardoso, Sandra W. | |
| Author | Bukuru, Aggrey | |
| Author | Makanga, Mumbi | |
| Author | Faesen, Sharlaa | |
| Author | Mave, Vidya | |
| Author | Wangari Ndege, Beatrice | |
| Author | Nerette Fontain, Sandy | |
| Author | Samaneka, Wadzanai | |
| Author | Secours, Rode | |
| Author | van Schalkwyk, Marije | |
| Author | Mngqibisa, Rosie | |
| Author | Mohapi, Lerato | |
| Author | Valencia, Javier | |
| Author | Sugandhavesa, Patcharaphan | |
| Author | Montalban, Esmelda | |
| Author | Avihingsanon, Anchalee | |
| Author | Santos, Breno R. | |
| Author | Kumarasamy, Nagalingeswaran | |
| Author | Kanyama, Cecilia | |
| Author | Schooley, Robert T. | |
| Author | Mellors, John W. | |
| Author | Wallis, Carole L. | |
| Author | Collier, Ann C. | |
| Access date | 2019-10-30T18:07:57Z | |
| Available date | 2019-10-30T18:07:57Z | |
| Document date | 2019 | |
| Citation | GRINSZTEJN, Beatriz et al. Third-line antiretroviral therapy in low-income and middle-income countries (ACTG A5288): a prospective strategy study. Lancet HIV, v. 6, n. 9, p. e588-e600, Sept. 2019. | pt_BR |
| ISSN | 2405-4704 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/36767 | |
| Description | A5288 Team: Grinsztejn B, Mugyenyi PN, Collier A, Salata R, Godfrey C, Hogg E, Hughes M, Ritz J, Wieclaw L, Sise T, Mellors JW, Wallis C, Fletcher CV, Gandhi M, Gross R, Schooley RT, Walensky R, van Schalkwyk M, Faesen S, Mngqibisa R, Valencia J, Montalban E, Kumarasamy N, Kanyama C, Cardoso SW, Santos BR, Mansfield B, Mugerwa H, Ndege BW, Secours R, Samaneka W, Kadam D, Mave V, Makanga M, Fontain SN, Sugandhavesa P, Avihingsanon A, Nakibuuka L, Nassolo H, Anthony P, Kulkarni V, Nsubuga M, van Wyk J, Rooney J, van Delft Y, Leavitt R, Luk R, Benns A, Hovind L, Shahkolahi A. | pt_BR |
| Sponsorship | National Institutes of Health. | pt_BR |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | open access | pt_BR |
| Title | Third-line antiretroviral therapy in low-income and middle-income countries (ACTG A5288): a prospective strategy study | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1016/S2352-3018(19)30146-8 | |
| Abstract | Antiretroviral therapy (ART) management is challenging for individuals in resource-limited settings presenting for third-line treatment because of complex resistance patterns, partly due to reduced access to viral load monitoring. We aimed to evaluate use of newer antiretroviral drugs and contemporary management approaches, including population-based sequencing, to select appropriate antiretrovirals, plasma viral load monitoring, and interventions to improve adherence in individuals presenting with second-line viral failure. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Harvard T H Chan School of Public Health, Boston, MA, USA. | pt_BR |
| Affilliation | Harvard T H Chan School of Public Health, Boston, MA, USA. | pt_BR |
| Affilliation | Department of Medicine, Case Western Reserve University, Cleveland, OH, USA | pt_BR |
| Affilliation | Joint Clinical Research Center, Kampala, Uganda. | pt_BR |
| Affilliation | Social & Scientific Systems, Inc, Silver Spring, MD, USA. | pt_BR |
| Affilliation | Frontier Science & Technology Research Foundation, Amherst, NY, USA. | pt_BR |
| Affilliation | Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA. | pt_BR |
| Affilliation | Division of AIDS, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Joint Clinical Research Center, Kampala, Uganda. | pt_BR |
| Affilliation | Kenya Medical Research Institute, Kisumu, Kenya; Center of Disease Control, Kisumu, Kenya. | pt_BR |
| Affilliation | Wits HIV Clinical Research Site, Johannesburg, South Africa. | pt_BR |
| Affilliation | BJ Medical College Clinical Research Site, Pune, India. | pt_BR |
| Affilliation | AMPATH, Moi University Teaching Hospital Eldoret Clinical Research Site, Eldoret, Kenya. | pt_BR |
| Affilliation | Les Centres GHESKIO Clinical Research Site, Port-au-Prince, Haiti. | pt_BR |
| Affilliation | University of Zimbabwe College of Health Sciences Clinical Trials Research Centre, University of Zimbabwe, Harare, Zimbabwe. | pt_BR |
| Affilliation | Les Centres GHESKIO Clinical Research Site, Port-au-Prince, Haiti. | pt_BR |
| Affilliation | Family Clinical Research Unit Clinical Research Site, Stellenbosch University, Cape Town, South Africa. | pt_BR |
| Affilliation | Durban Adult HIV Clinical Research Site, Enhancing Care Foundation, Durban, South Africa. | pt_BR |
| Affilliation | Soweto AIDS Clinical Trials Group Clinical Research Site, University of the Witwatersrand, Johannesburg, South Africa. | pt_BR |
| Affilliation | Barranco Clinical Research Site, Lima, Peru. | pt_BR |
| Affilliation | Center for AIDS and STDs, Chiang Mai University, Chiang Mai, Thailand. | pt_BR |
| Affilliation | San Miguel Clinical Research Site, Lima, Peru. | pt_BR |
| Affilliation | Thai Red Cross AIDS Research Center Treatment Clinical Research Site, Bangkok, Thailand. | pt_BR |
| Affilliation | Serviço de Infectologia, Hospital Nossa Senhora da Conceicao, Grupo Hospitalar Conceição, Porto Alegre, Brazil. | pt_BR |
| Affilliation | Chennai Antiviral Research and Treatment Clinical Research Site, Chennai, India. | pt_BR |
| Affilliation | University of North Carolina Project, Kamuzu Central Hospital, Lilongwe, Malawi. | pt_BR |
| Affilliation | Division of Infectious Disease, University of California, San Diego, CA, USA. | pt_BR |
| Affilliation | Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. | pt_BR |
| Affilliation | Bio Analytical Research Corporation South Africa, Lancet Laboratories, Johannesburg, South Africa. | pt_BR |
| Affilliation | University of Washington School of Medicine, University of Washington, Seattle, WA, USA. | pt_BR |
| Subject | Antiretroviral therapy | pt_BR |
| Subject | HIV-1 | pt_BR |
| Subject | Drug resistence | pt_BR |
| Subject | AIDS | pt_BR |
