| Author | Suffys, Philip N. | |
| Author | Araujo, Marcelo E. Ivens de | |
| Author | Degrave, Wim M. | |
| Access date | 2019-11-02T20:05:03Z | |
| Available date | 2019-11-02T20:05:03Z | |
| Document date | 1997 | |
| Citation | SUFFYS, Philip N.; ARAUJO, Marcel E. Ivens de; DEGRAVE, Wim M. The Changing Face of the Epidemiology of Tuberculosis due to Molecular Strain Typing - A Review. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 92, n. 3, p. 297-316, May/June 1997. | pt_BR |
| ISSN | 0074-0276 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/36814 | |
| Language | eng | pt_BR |
| Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Tuberculose | pt_BR |
| Subject in Portuguese | Epidemiologia molecular | pt_BR |
| Subject in Portuguese | Impressões digitais | pt_BR |
| Subject in Portuguese | Polimorfismo do comprimento do fragmento da limitação | pt_BR |
| Title | The changing face of the epidemiology of tuberculosis due to molecular strain typing--a review | pt_BR |
| Type | Article | |
| DOI | 10.1590/s0074-02761997000300001 | |
| Abstract | About one third of the world population is infected with tubercle bacilli, causing eight million new cases of tuberculosis (TB) and three million deaths each year. After years of lack of interest in the disease, World Health Organization recently declared TB a global emergency and it is clear that there is need for more efficient national TB programs and newly defined research priorities. A more complete epidemiology of tuberculosis will lead to a better identification of index cases and to a more efficient treatment of the disease. Recently, new molecular tools became available for the identification of strains of Mycobacterium tuberculosis (M. tuberculosis), allowing a better recognition of transmission routes of defined strains. Both a standardized restriction-fragment-length-polymorphism-based methodology for epidemiological studies on a large scale and deoxyribonucleic acids (DNA) amplification-based methods that allow rapid detection of outbreaks with multidrug-resistant (MDR) strains, often characterized by high mortality rates, have been developed. This review comments on the existing methods of DNA-based recognition of M. tuberculosis strains and their peculiarities. It also summarizes literature data on the application of molecular fingerprinting for detection of outbreaks of M. tuberculosis, for identification of index cases, for study of interaction between TB and infection with the human immuno-deficiency virus, for analysis of the behavior of MDR strains, for a better understanding of risk factors for transmission of TB within communities and for population-based studies of TB transmission within and between countries. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Laboratório de Biologia Molecular e Diagnóstico de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Laboratório de Biologia Molecular e Diagnóstico de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Laboratório de Biologia Molecular e Diagnóstico de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Tuberculosis | pt_BR |
| Subject | Molecular epidemiology | pt_BR |
| Subject | Fingerprinting | pt_BR |
| Subject | Restriction fragment length polymorphism | pt_BR |
| e-ISSN | 1678-8060 | |
