Author | Correa, Juan Rivera | |
Author | Siqueira, Isadora Cristina de | |
Author | Mota, Sabrina | |
Author | Rosário, Mateus Santana do | |
Author | Jesus, Pedro Antônio Pereira de | |
Author | Alcantara, Luiz Carlos Junior | |
Author | Ernst, Joel D. | |
Author | Rodriguez, Ana | |
Access date | 2019-11-04T13:11:27Z | |
Available date | 2019-11-04T13:11:27Z | |
Document date | 2019 | |
Citation | CORREA, Juan Rivera et al. Anti-ganglioside antibodies in patients with Zika virus infection-associated Guillain-Barre Syndrome in Brazil. PLoS Neglected Tropical Disease, v. 13, n. 9, p. 1-13, 2019. | pt_BR |
ISSN | 1935-2727 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/36827 | |
Sponsorship | AR and JRC received funding for this project from New York University School of Medicine Internal Funds. | pt_BR |
Language | eng | pt_BR |
Publisher | Public Library of Science | pt_BR |
Rights | open access | |
Subject in Portuguese | Virus zika | pt_BR |
Subject in Portuguese | Síndrome de Guillain-Barré | pt_BR |
Subject in Portuguese | Gangliosídeos | pt_BR |
Subject in Portuguese | Brasil | pt_BR |
Title | Anti-ganglioside antibodies in patients with Zika virus infection-associated Guillain-Barre Syndrome in Brazil | pt_BR |
Type | Article | |
DOI | 10.1371/journal.pntd.0007695 | |
Abstract | Zika virus infection is associated with the development of Guillain-Barré syndrome (GBS), a neurological autoimmune disorder caused by immune recognition of gangliosides and other components at nerve membranes. Using a high-throughput ELISA, we have analyzed the anti-glycolipid antibody profile, including gangliosides, of plasma samples from patients with Zika infections associated or not with GBS in Salvador, Brazil. We have observed that Zika patients that develop GBS present higher levels of anti-ganglioside antibodies when compared to Zika patients without GBS. We also observed that a broad repertoire of gangliosides was targeted by both IgM and IgG anti-self antibodies in these patients. Since Zika virus infects neurons, which contain membrane gangliosides, antigen presentation of these infected cells may trigger the observed autoimmune anti-ganglioside antibodies suggesting direct infection-induced autoantibodies as a cause leading to GBS development. Collectively, our results establish a link between anti-ganglioside antibodies and Zika-associated GBS in patients. | pt_BR |
Affilliation | New York University School of Medicine. Departament of Microbiology. New York, NY, United States of America. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | New York University School of Medicine. Departament of Microbiology. New York, NY, United States of America. | pt_BR |
Affilliation | Hospital Santa Izabel. Salvador, BA, Brasil. | pt_BR |
Affilliation | Secretaria Estadual da Saúde da Bahia. Hospital Geral Roberto Santos. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | New York University School of Medicine. Departament of Microbiology. New York, NY, United States of America / University of California. Division of Experimental Medicine. San Francisco, CA, United States of America. | pt_BR |
Affilliation | New York University School of Medicine. Departament of Microbiology. New York, NY, USA. | pt_BR |
Subject | Zika virus | pt_BR |
Subject | Guillain-Barre Syndrome | pt_BR |
Subject | Gangliosides | pt_BR |
Subject | Brazil | pt_BR |
Embargo date | 2020-01-06 | |