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AutorAndrade, Kaio Vinicius Freitas dept_BR
AutorNery, Joilda Silvapt_BR
AutorPescarini, Júlia Moreirapt_BR
AutorRamond, Annapt_BR
AutorSantos, Carlos Antônio de Souza Telespt_BR
AutorIchihara, Maria Yury Travassospt_BR
AutorPenna, Maria Lucia Fernandespt_BR
AutorBrickley, Elizabeth B.pt_BR
AutorRodrigues, Laura Cunhapt_BR
AutorSmeeth, Liampt_BR
AutorBarreto, Mauricio Limapt_BR
AutorPereira, Susan Martinspt_BR
AutorPenna, Gerson Oliveirapt_BR
Fecha de acceso2019-11-04T14:28:51Z
Fecha de disponibilización2019-11-04T14:28:51Z
Fecha de publicación2019
ReferenciaANDRADE, Kaio Vinicius Freitas de et al. Geographic and socioeconomic factors associated with leprosy treatment default: an analysis from the 100 Million Brazilian Cohort. Plos Neglected Tropical Diseases, p. 1-18, Sept. 2019.pt_BR
ISSN1935-2727pt_BR
URIhttps://www.arca.fiocruz.br/handle/icict/36841
PromociónMedical Research Council (MRC) (MR/N017250/1), CONFAP/ESRC/MRC/BBSRC/CNPq/FAPDF 2015 – Neglected Tropical Diseases (Process number FAP-DF 193.000.008/2016) to Gerson Oliveira Penna, and Wellcome Trust (Grant 202912/Z/16/Z).pt_BR
Idiomaengpt_BR
EditorPublic Library of Sciencept_BR
Derechos de autoropen accesspt_BR
Palabras clave en PortuguésFatores socioeconomicospt_BR
Palabras clave en PortuguésHanseniasept_BR
Palabras clave en PortuguésTratamentopt_BR
Palabras clave en PortuguésAnálise de Coortespt_BR
TítuloGeographic and socioeconomic factors associated with leprosy treatment default: an analysis from the 100 Million Brazilian Cohorten
Tipo del documentoArticlept_BR
DOI10.1371/journal.pntd.0007714
Resumen en InglésAlthough leprosy is largely curable with multidrug therapy, incomplete treatment limits therapeutic effectiveness and is an important obstacle to disease control. To inform efforts to improve treatment completion rates, we aimed to identify the geographic and socioeconomic factors associated with leprosy treatment default in Brazil. Methodology/Principal findings Using individual participant data collected in the Brazilian national registries for social programs and notifiable diseases and linked as part of the 100 Million Brazilian Cohort, we evaluated the odds of treatment default among 20,063 leprosy cases diagnosed and followed up between 2007 and 2014. We investigated geographic and socioeconomic risk factors using a multivariate hierarchical analysis and carried out additional stratified analyses by leprosy subtype and geographic region. Over the duration of follow-up, 1,011 (5.0%) leprosy cases were observed to default from treatment. Treatment default was markedly increased among leprosy cases residing in the North (OR = 1.57; 95%CI 1.25–1.97) and Northeast (OR = 1.44; 95%CI 1.17–1.78) regions of Brazil.en
AfiliaciónFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil / Federal University of Bahia. Institute of Collective Health. Salvador, BA, Brazil / State University of Feira de Santana. Department of Health. Feira de Santana, BA, Brazil.pt_BR
AfiliaciónFederal University of Bahia. Institute of Collective Health. Salvador, BA, Brazilpt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil / Universidade Federal da Bahia, Instituto de Matemática. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasilpt_BR
AfiliaciónLondon School of Hygiene & Tropical Medicine. Department of Infectious Disease Epidemiology. London, United Kingdom.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil / Federal University of Bahia. Institute of Collective Health. Salvador, BA, Brasilpt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil.pt_BR
AfiliaciónFederal University Fluminense. Department of Epidemiology and Biostatistics. Rio de Janeiro, RJ, Brazil.pt_BR
AfiliaciónLondon School of Hygiene & Tropical Medicine. Department of Infectious Disease Epidemiology. London, United Kingdom.pt_BR
AfiliaciónLondon School of Hygiene & Tropical Medicine. Department of Infectious Disease Epidemiology. London, United Kingdom.pt_BR
AfiliaciónLondon School of Hygiene & Tropical Medicine. Department of Non-communicable Disease Epidemiology. London, United Kingdom.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil / Federal University of Bahia. Institute of Collective Health. Salvador, BA, Brazil.pt_BR
AfiliaciónFederal University of Bahia. Institute of Collective Health. Salvador, BA, Brazil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Fiocruz Brasília. Escola de Governo. Brasília, DF, Brasil / Universidade de Brasília. Centro de Medicina Tropical. Brasília, DF, Brasil.pt_BR
Palavras clave en InglêsSocioeconomic Factorsen
Palavras clave en InglêsLeprosyen
Palavras clave en InglêsTreatmenten
Palavras clave en InglêsCohort Studiesen
xmlui.metadata.dc.subject.ods01 Erradicação da pobreza


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