| Author | Guedes, Diego Lins | |
| Author | Medeiros, Zulma | |
| Author | Silva, Elis Dionísio da | |
| Author | Vasconcelos, Audrey Violeta Martins de | |
| Author | Silva, Mariana Santana da | |
| Author | Silva, Maria Almerice Lopes da | |
| Author | Araújo, Paulo Sérgio Ramos de | |
| Author | Miranda-Filho, Demócrito de Barros | |
| Access date | 2019-11-04T15:11:49Z | |
| Available date | 2019-11-04T15:11:49Z | |
| Document date | 2018 | |
| Citation | GUEDES, Diego Lins et al. Visceral Leishmaniasis in Hospitalized HIV-Infected Patients in Pernambuco, Brazil. The American Journal of Tropical Medicine and Hygiene, v. 99, n. 6, p. 1541-1546, 2018. | pt_BR |
| ISSN | 0002-9637 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/36844 | |
| Language | eng | pt_BR |
| Rights | restricted access | pt_BR |
| Title | Visceral Leishmaniasis in Hospitalized HIV-Infected Patients in Pernambuco, Brazil | pt_BR |
| Type | Article | |
| DOI | 10.4269/ajtmh.17-0787 | |
| Abstract | Common in four continents, visceral leishmaniasis (VL) is an important but neglected disease. Human immunodeficiency virus (HIV) infection increases the risk of developing VL in people from leishmaniasis-endemic areas, with worse prognosis when there is coinfection. We conducted a cross-sectional study to determine the prevalence of HIV/VL coinfection in patients admitted in three referral hospitals for HIV/acquired immunodeficiency syndrome (AIDS) in Pernambuco, Brazil, and to compare epidemiological, clinical, and laboratory characteristics among HIV/VL coinfected and HIV mono-infected individuals. The sample consisted of HIV patients aged 18 years or more, in a period of data collection of 6 months. We performed four Leishmania tests-polymerase chain reaction (PCR), direct agglutination test, rK39, and latex agglutination test-and individuals with at least one positive test were considered coinfected. The HIV/VL coinfection prevalence we found was 16.9%. We observed large variation in prevalence according to the Leishmania test used, with low coincidence of positive tests. The most frequent symptoms found were weight loss (75.6%), fever (67.6%), and cough (55.3%). When we compared HIV/VL coinfected and HIV mono-infected groups we did not observe statistically significant differences. Low educational level (P = 0.004) and pallor (P = 0.009) were more frequent in the coinfected group. Serum albumin level was higher in coinfected individuals (P = 0.009). It is important to follow-up these individuals to understand the dynamics of VL in people living with HIV. New tests are necessary, ideally differentiating active from latent infection. Testing for VL in people with HIV is important and should be considered as part of the initial investigation in these individuals. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Parasitologia. Recife, PE, Brasil / Universidade Federal de Pernambuco. Núcleo de Ciências da Vida. Curso de Medicina. Caruaru, PE, Brasil. | pt_BR |
| Affilliation | Universidade de Pernambuco. Instituto de Ciências Biológicas. Recife, PE, Brasil / Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Parasitologia. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Parasitologia. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação de Hematologia e Hemoterapia de Pernambuco. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Parasitologia. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Parasitologia. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Parasitologia. Recife, PE, Brasil. | pt_BR |
| Affilliation | Universidade de Pernambuco. Faculdade de Ciências Médicas. Recife, PE, Brasil. | pt_BR |
| Subject | Visceral Leishmaniasis | pt_BR |
| Subject | HIV-Infected Patients | pt_BR |
| Subject | Brazil | pt_BR |
| DeCS | Adolescente | pt_BR |
| DeCS | Adulto | pt_BR |
| DeCS | Testes de Aglutinação | pt_BR |
| DeCS | Brasil / epidemiologia | pt_BR |
| DeCS | Coinfecção | pt_BR |
| DeCS | Estudos Transversais | pt_BR |
| DeCS | Feminino | pt_BR |
| DeCS | HIV / genética | pt_BR |
| DeCS | HIV / imunologia | pt_BR |
| DeCS | HIV/ / isolamento & purificação | pt_BR |
| DeCS | Infecções por HIV / epidemiologia | pt_BR |
| DeCS | Infecções por HIV / parasitologia | pt_BR |
| DeCS | Infecções por HIV / fisiopatologia | pt_BR |
| DeCS | Infecções por HIV / virologia | pt_BR |
| DeCS | Hospitalização | pt_BR |
| DeCS | Humanos | pt_BR |
| DeCS | Leishmania / genética | pt_BR |
| DeCS | Leishmania / imunologia | pt_BR |
| DeCS | Leishmania / isolamento & purificação | pt_BR |
| DeCS | Leishmaniose Visceral / epidemiologia | pt_BR |
| DeCS | Leishmaniose Visceral / parasitologia | pt_BR |
| DeCS | Leishmaniose Visceral / fisiopatologia | pt_BR |
| DeCS | Leishmaniose Visceral / virologia | pt_BR |
| DeCS | Masculino | pt_BR |
| DeCS | Pessoa de Meia-Idade | pt_BR |
| DeCS | Reação em Cadeia da Polimerase | pt_BR |
| DeCS | Epidemiologia | pt_BR |
| Embargo date | 2050-01-01 | |
