| Author | Paz, Weider H. P. | |
| Author | Oliveira, Rodolfo N. de | |
| Author | Heerdt, Gabriel | |
| Author | Angolini, Célio F. F. | |
| Author | Medeiros, Lívia S. de | |
| Author | Silva, Valdenizia Rodrigues | |
| Author | Santos, Luciano de Souza | |
| Author | Soares, Milena Botelho Pereira | |
| Author | Bezerra, Daniel Pereira | |
| Author | Morgon, Nelson H. | |
| Author | Almeida, Jackson Moura Araujo da | |
| Author | Silva, Felipe Moura Araujo da | |
| Author | Costa, Emmanoel Vilaça | |
| Author | Koolen, Héctor Henrique Ferreira | |
| Access date | 2019-11-04T17:25:54Z | |
| Available date | 2019-11-04T17:25:54Z | |
| Document date | 2019 | |
| Citation | PAZ, Weider H. P. et al. Structure-Based Molecular Networking for the Target Discovery of Oxahomoaporphine and 8-Oxohomoaporphine Alkaloids from Duguetia surinamensis. Journal of Natural Products, v. 82, p. 2220−2228, 2019. | pt_BR |
| ISSN | 0163-3864 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/36849 | |
| Sponsorship | ACS Publications website at DOI: 10.1021/acs.jnatprod.
9b00287 | pt_BR |
| Language | eng | pt_BR |
| Publisher | American Society of Pharmacognosy | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | Alcaloides | pt_BR |
| Subject in Portuguese | Annonaceae | pt_BR |
| Subject in Portuguese | Amazonia | pt_BR |
| Subject in Portuguese | Floresta Tropical | pt_BR |
| Title | Structure-Based Molecular Networking for the Target Discovery of Oxahomoaporphine and 8-Oxohomoaporphine Alkaloids from Duguetia surinamensis | pt_BR |
| Type | Article | |
| DOI | 10.1021/acs.jnatprod.9b00287 | |
| Abstract | In addition to seven known alkaloids (2, 6-11) and 1,2,4-trimethoxybenzene (1), three isoquinoline-derived alkaloids (3-5), namely, duguetinine (3), a compound based on an unprecedented oxahomoaporphine scaffold, and two new 8-oxohomoaporphine alkaloids, duguesuramine (4) and 11-methoxyduguesuramine (5), and a new asarone-derived phenylpropanoid (10) were isolated from the bark of Duguetia surinamensis. The isolation workflow was guided by HPLC-HRESIMS/MS and molecular networking-based analyses. Twenty-four known alkaloids were dereplicated from the D. surinamensis alkaloid-rich fraction network and were assigned by manual MS/MS interpretation. Their cytotoxic potential was evaluated. | pt_BR |
| Affilliation | Amazonas State University. Metabolomics and Mass Spectrometry Research Group. Manaus, AM, Brazil / Federal University of Amazonas. Department of Chemistry. Manaus, AM, Brazil. | pt_BR |
| Affilliation | Federal University of Amazonas. Department of Chemistry. Manaus, AM, Brazil. | pt_BR |
| Affilliation | Federal University of Minas Gerais. Department of Chemistry. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Federal University of ABC. Center of Human and Natural Sciences. Santo André, SP, Brazil. | pt_BR |
| Affilliation | Federal University of São Paulo. Department of Chemistry. Diadema, SP, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | University of Campinas. Institute of Chemistry. Campinas, SP, Brazil. | pt_BR |
| Affilliation | Federal University of Vale do São Francisco. Center for Study and Research of Medicinal Plants. Petrolina, PE, Brazil. | pt_BR |
| Affilliation | Federal University of Amazonas. Department of Chemistry. Manaus, AM, Brazil. | pt_BR |
| Affilliation | Federal University of Amazonas. Department of Chemistry. Manaus, AM, Brazil. | pt_BR |
| Affilliation | Amazonas State University. Metabolomics and Mass Spectrometry Research Group. Manaus, AM, Brazil. | pt_BR |
| Subject | Alkaloids | pt_BR |
| Subject | Annonaceae | pt_BR |
| Subject | Amazonian Ecosystem | pt_BR |
| Subject | Rainforest | pt_BR |
| xmlui.metadata.dc.subject.ods | 15 Vida terrestre | |
