| Author | Santos-Oliveira, Joanna R. | |
| Author | Da-Cruz, Alda M. | |
| Author | Pires, Lucy H. S. | |
| Author | Cupolillo, Elisa | |
| Author | Kuhls, Katrin | |
| Author | Giacoia-Gripp, Carmem B. W. | |
| Author | Oliveira-Neto, Manoel P. | |
| Access date | 2019-11-05T14:37:20Z | |
| Available date | 2019-11-05T14:37:20Z | |
| Document date | 2011 | |
| Citation | SANTOS-OLIVEIRA, Joanna R. et al. Case report: atypical lesions as a sign of cutaneous dissemination of Visceral Leishmaniasis in a Human Immunodeficiency Virus-positive patient simultaneously infected by two viscerotropic Leishmania species. American Journal of Tropical Medicine and Hygiene, v. 85, n. 1, p. 55-59, 2011. | pt_BR |
| ISSN | 0002-9637 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/36868 | |
| Language | eng | pt_BR |
| Publisher | American Society of Tropical Medicine and Hygiene | pt_BR |
| Rights | open access | |
| Title | Case report: atypical lesions as a sign of cutaneous dissemination of visceral leishmaniasis in a human immunodeficiency virus-positive patient simultaneously infected by two viscerotropic Leishmania species | pt_BR |
| Type | Article | |
| DOI | 10.4269/ajtmh.2011.10-0398 | |
| Abstract | Leishmaniasis is considered an emerging opportunistic disease in human immunodeficiency virus (HIV)–
infected patients who have considerably variable clinical presentation. We report a patient with visceral leishmaniasis who had unexpected clinical aspects (atypical cutaneous lesions appearing after long-term evidence of visceral parasites). The patient had hepatoesplenomegaly in the absence of fever, but was otherwise generally healthy. The HIV viral load was low despite severe immunossupression (low lymphocyte proliferation and low level of interferon-γ, concomitant with a high lymphocyte activation status). Surprisingly, two Leishmania strains were isolated from his bone marrow (typical L. infantum sequence MON-1, type A) and skin (L. donovani MON-2 sequence); this second strain had not been previously identified in Brazil. The association of visceral leishmaniasis and HIV/acquired immunodeficiency syndrome is a largely unknown disease, particularly in areas in which leishmaniasis is not endemic. Such atypical cases indicate that this disease can be undiagnosed in clinical settings. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Secretaria Municipal de Saúde de Cabo Frio. Cabo Frio, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Charité University Medicine Berlin. Institute of Microbiology and Hygiene. Berlin, Germany. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Visceral leishmaniasis | pt_BR |
| Subject | Atypical lesions | pt_BR |
| Subject | Human Immunodeficiency Virus | pt_BR |
| Subject | Viscerotropic Leishmania species | pt_BR |
| e-ISSN | 1476-1645 | |
| Embargo date | 2020-11-05 | |
