| Author | Vieira, Giciane C. | |
| Author | Gadelha, Francisco A. A. F. | |
| Author | Pereira, Raquel F. | |
| Author | Ferreira, Laércia K. D. P. | |
| Author | Barbosa Filho, José M. | |
| Author | Bozza, Patrícia T. | |
| Author | Piuvezam, Marcia R. | |
| Access date | 2019-11-06T16:22:17Z | |
| Available date | 2019-11-06T16:22:17Z | |
| Document date | 2018 | |
| Citation | VIEIRA, Giciane C. et al. Warifteine, an alkaloid of Cissampelos sympodialis, modulates allergic profile in a chronic allergic rhinitis model. Revista Brasileira de Farmacognosia, Curitiba, v. 28, n. 1, p. 50-56, 2018. | pt_BR |
| ISSN | 0102-695X | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/36906 | |
| Language | eng | pt_BR |
| Publisher | Universidade Federal do Paraná. Laboratório de Farmacognosia | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Rinite alérgica | pt_BR |
| Subject in Portuguese | Tecidos nasais | pt_BR |
| Subject in Portuguese | Mastócitos | pt_BR |
| Subject in Portuguese | Imunoglobulina E | pt_BR |
| Title | Warifteine, an alkaloid of Cissampelos sympodialis, modulates allergic profile in a chronic allergic rhinitis model | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.bjp.2017.10.009 | |
| Abstract | Cissampelos sympodialis Eichler, Menispermaceae, a Brazilian medicinal plant and its alkaloid warifteine present immunomodulatory activity on asthma experimental model by reducing antigen-specific IgE levels, eosinophil infiltration and lung hyperactivity. Allergic rhinitis is a chronic inflammatory disorder of the nasal tissue that affect the quality of life and it is a risk factor for asthma exacerbation. This study evaluated the effect of inhaled warifteine in an allergic ovalbumin rhinitis model. Inhaled warifteine (2 mg/ml) treatment of ovalbumin-sensitized BALB/c mice significant decreased total and differential number of cells on the nasal cavity and decreased ovalbumin-specific IgE serum levels. Hematoxylin & eosin staining of histological preparations of ovalbumin nasal tissues showed changes such as congestion and a massive cell infiltration in the perivascular and subepithelial regions characterizing the nasal inflammatory process. However, inhaled warifteine or dexamethasone treatment decreased cell infiltration into the perivascular regions and it was observed an intact nasal tissue. Periodic acidic staining of nasal epithelium of ovalbumin animals demonstrated high amount of mucus production by goblet cells and inhaled warifteine or dexamethasone treatment modulated the mucus production. In addition, toluidine blue staining of the nasal epithelium of ovalbumin animals demonstrated an increase of mast cells on the tissue and inhaled warifteine or dexamethasone treatment decreased in average of 1.4 times the number of these cells on the nasal epithelium. Taken these data together we postulate that warifteine, an immunomodulatory alkaloid, can be a medicinal molecule prototype to ameliorate the allergic rhinitis conditions. | pt_BR |
| Affilliation | Universidade Federal da Paraíba. Centro de Ciências da Saúde. Departamento de Morfologia. Laboratório de Imunofarmacologia. João Pessoa, PB, Brasil. | pt_BR |
| Affilliation | Universidade Federal da Paraíba. Centro de Ciências da Saúde. Departamento de Fisiologia e Patologia. Laboratório de Imunofarmacologia. João Pessoa, PB, Brasil. | pt_BR |
| Affilliation | Universidade Federal da Paraíba. Centro de Ciências da Saúde. Departamento de Morfologia. Laboratório de Imunofarmacologia. João Pessoa, PB, Brasil. | pt_BR |
| Affilliation | Universidade Federal da Paraíba. Centro de Ciências da Saúde. Departamento de Fisiologia e Patologia. Laboratório de Imunofarmacologia. João Pessoa, PB, Brasil. | pt_BR |
| Affilliation | Universidade Federal da Paraíba. Centro de Ciências da Saúde. Departamento de Ciências Farmacêuticas. Laboratório de Fitoquímica. João Pessoa, PB, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal da Paraíba. Centro de Ciências da Saúde. Departamento de Fisiologia e Patologia. Laboratório de Imunofarmacologia. João Pessoa, PB, Brasil. | pt_BR |
| Subject | Allergic rhinitis | pt_BR |
| Subject | Eosinophil | pt_BR |
| Subject | IgE | pt_BR |
| Subject | Nasal tissues | pt_BR |
| Subject | Mast cells | pt_BR |
| Subject | Warifteine | pt_BR |
| DeCS | Imunoglobulina E | pt_BR |
| e-ISSN | 1981-528X | |
