| Author | Azevedo, Elisa de A. N. | |
| Author | Barreto, Silvana | |
| Author | Lima, Raul Emídio de | |
| Author | Teixeira, Romero Henrique | |
| Author | Diniz, George | |
| Author | Oliveira, Wilson | |
| Author | Cavalcanti, Maria da Glória A. M. | |
| Author | Gomes, Yara M. | |
| Author | Moura, Patrícia M. M. de F. | |
| Author | Morais, Clarice N. L. | |
| Access date | 2019-11-13T13:48:03Z | |
| Available date | 2019-11-13T13:48:03Z | |
| Document date | 2018 | |
| Citation | AZEVEDO, Elisa de A. N. et al. Binding capacity of mannose-binding lectin (MBL) is associated with the severity of chronic Chagas cardiomyopathy. Parasitology International, v. 67, n. 5, p. 593–596, 2018. | pt_BR |
| ISSN | 1383-5769 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/37027 | |
| Sponsorship | Fundação de Amparo à Ciência e Tecnologia de Pernambuco ; Conselho Nacional de Desenvolvimento Científico e Tecnológico | pt_BR |
| Language | eng | pt_BR |
| Rights | restricted access | |
| Title | Binding capacity of mannose-binding lectin (MBL) is associated with the severity of chronic Chagas cardiomyopathy | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.parint.2018.05.009 | |
| Abstract | Chagas disease (CD) is a global problem. Currently, it affects approximately 15 million individuals in Latin America. It is well know that the human immune response is related to different clinical manifestations. Mannose binding lectin (MBL) plays an important role in innate immunity, and it mediates the phagocytosis and complement-mediated destruction of pathogens. The binding capacity is enhanced by the oligomerization of MBL. In this study, we evaluated the serum concentration and the binding capacity of MBL in patients with chronic chagasic cardiomyopathy. A total of 77 patients with chronic CD were included with indeterminate (n = 19), mild cardiac (n = 29) and severe cardiac (n = 29) forms. The serum concentration and the binding capacity were measured using enzyme-linked immunosorbent assays (ELISA). There was no significant difference in the serum MBL levels between the groups of patients. However, we found a relationship between the binding capacity and the groups studied. Our results suggest that binding capacity of MBL could be an indicator of clinical manifestation in Chronic Chagas cardiomyopathy. Furthermore, combined with the Mannose Binding Index results in a useful clinical tool for management of Chronic Chagas Patients. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil. | pt_BR |
| Affilliation | Universidade de Pernambuco. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil. | pt_BR |
| Affilliation | Universidade Federal da Paraíba. João Pessoa, PB, Brasil / Empresa Brasileira de Serviços Hospitalares. Hospital Universitário Lauro Wanderley. João Pessoa, PB, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil. | pt_BR |
| Affilliation | Universidade de Pernambuco. Pronto-Socorro Cardiológico Universitário de Pernambuco - Prof. Luiz Tavares. Ambulatório de Doença de Chagas e Insuficiência Cardíaca. Recife, PE, Brasil. | pt_BR |
| Affilliation | Universidade de Pernambuco. Pronto-Socorro Cardiológico Universitário de Pernambuco - Prof. Luiz Tavares. Ambulatório de Doença de Chagas e Insuficiência Cardíaca. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Programa Integrado de Doença de Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade de Pernambuco. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães, PE, Brasil. | pt_BR |
| Subject | Chagas cardiomyopathy | pt_BR |
| Subject | Chagas disease | pt_BR |
| Subject | Innate immunity | pt_BR |
| Subject | Mannose-binding lectin | pt_BR |
| DeCS | Cardiomiopatia Chagásica / imunologia | pt_BR |
| DeCS | Cardiomiopatia Chagásica / patologia | pt_BR |
| DeCS | Doença Crônica | pt_BR |
| DeCS | Ensaio de Imunoadsorção Enzimática | pt_BR |
| DeCS | Humanos | pt_BR |
| DeCS | Imunidade Inata | pt_BR |
| DeCS | Lectina de Ligação a Manose / sangue | pt_BR |
| DeCS | Lectina de Ligação a Manose | pt_BR |
| DeCS | Ligação Proteica | pt_BR |
| e-ISSN | 1873-0329 | |
| Embargo date | 2050-01-01 | |
