| Author | Mota, Ester Maria | |
| Author | Lenzi, Henrique Leonel | |
| Access date | 2011-12-15T23:36:56Z | |
| Available date | 2011-12-15T23:36:56Z | |
| Document date | 2005 | |
| Citation | MOTA, Ester Maria; LENZI, Henrique Leonel. Angiostrongylus costaricensis: complete redescription of the migratory pathways based on experimental Sigmodon hispidus infection. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 100, n. 4, p. 407-420, 2005. | pt_BR |
| ISSN | 0074-0276 | |
| URI | https://www.arca.fiocruz.br/handle/icict/3721 | |
| Description | Acknowledgments to Dr Marcelo Pelajo Machado for his criticism towards the manuscript and for his excellent participation in the theoretical discussion on the subject. To LF Caputo for her technical assistance. | pt_BR |
| Language | eng | pt_BR |
| Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz | pt_BR |
| Rights | open access | |
| Title | Angiostrongylus costaricensis: complete redescription of the migratory pathways based on experimental Sigmodon hispidus infection | pt_BR |
| Type | Article | |
| DOI | http://www.scielo.br/pdf/mioc/v100n4/v100n4a12.pdf | |
| Abstract | Angiostrongylus costaricensis lives in the cecal and mesenteric arteries of its vertebrate hosts, and causes an inflammatory disease in humans. To investigate unknown aspects of the abdominal angiostrogyliasis pathogenesis, infected Sigmodon hispidus were sequentially studied in different times of infection. The study revealed that L3 goes alternatively through two migratory courses during its development into an adult worm: lymphatic/venous-arterial and venous portal pathways. The former is considered the principal one, because it is used by most of the larvae. Like other metastrongylides, A. costaricensis passes over the pulmonary circulation to migrate from the lymphatic system to the arterial circulation, where they circulate during some days before reaching their definitive habitat. The oviposition by mature females began on 15th day. Eggs and L1 were detected mainly in the intestine and stomach, surrounded by inflammatory reaction constituted by macrophages, monocytes, and eosinophils. They were also spread to the lungs, mesenteric lymph nodes, pancreas, spleen, and kidneys. The larvae (L1) exhibited the centripetal capacity to invade the lymphatic and venous vessels of the intestine and mesentery. Adult worms that developed in the venous intrahepatic pathway migrated downstream to reach the mesenteric veins and laid eggs that embolized in the portal hepatic vessels. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil | pt_BR |
| Subject | Angiostrongylus costaricensis | pt_BR |
| Subject | Life Cycle | pt_BR |
| Subject | Sigmodon hispidus | pt_BR |
| Subject | Liver | pt_BR |
| DeCS | Angiostrongylus | pt_BR |
| DeCS | Fases do Ciclo de Vida | pt_BR |
| DeCS | Fígado | pt_BR |
