Author | Sallenave-Sales, Selma | |
Author | Faria, Clarissa Perez | |
Author | Zalis, Mariano Gustavo | |
Author | Ribeiro, Cláudio Tadeu Daniel | |
Author | Cruz, Maria de Fátima Ferreira da | |
Access date | 2019-11-26T15:01:56Z | |
Available date | 2019-11-26T15:01:56Z | |
Document date | 2007 | |
Citation | SALLENAVE-SALES, Selma et al. Merozoite surface protein 2 allelic variation influences the specific antibody response during acute malaria in individuals from a Brazilian endemic area. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 102, n. 3, p. 421-424, June 2007. | pt_BR |
ISSN | 0074-0206 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/37390 | |
Language | eng | pt_BR |
Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Plasmodium falciparum | pt_BR |
Subject in Portuguese | Malária | pt_BR |
Subject in Portuguese | Proteína-2 da superfície do merozoito | pt_BR |
Subject in Portuguese | Resposta de anticorpos | pt_BR |
Subject in Portuguese | Polimorfismo antigênico | pt_BR |
Title | Merozoite surface protein 2 allelic variation influences the specific antibody response during acute malaria in individuals from a Brazilian endemic area | pt_BR |
Type | Article | pt_BR |
DOI | 10.1590/S0074-02762007005000048 | |
Abstract | The antibody response to Plasmodium falciparum parasites of naturally infected population is critical to
elucidate the role of polymorphic alleles in malaria. Thus, we evaluated the impact of antigenic diversity of
repetitive and family dimorphic domains of the merozoite surface protein 2 (MSP-2) on immune response of 96
individuals living in Peixoto de Azevedo (MT-Brazil), by ELISA using recombinant MSP-2 proteins. The majority
of these individuals were carrying FC27-type infections. IgG antibody responses were predominantly directed
to FC27 parasites and were correlated to the extension of polymorphism presented by each MSP-2
region. This finding demonstrated the impact of the genetic polymorphism on antibody response and therefore,
its importance on malaria vaccine efficacy. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Departamento de Medicina Preventiva. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Departamento de Medicina Preventiva. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Centro Colaborador WHO para . Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro Colaborador da WHO para Pesquisa e Treinamento em Imunologia de Doenças Parasitárias. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro Colaborador da WHO para Pesquisa e Treinamento em Imunologia de Doenças Parasitárias. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Plasmodium falciparum | pt_BR |
Subject | Merozoite surface protein-2 | pt_BR |
Subject | Antibody response | pt_BR |
Subject | Antigenic polymorphism | pt_BR |
Subject | Malaria | pt_BR |
e-ISSN | 1678-8060 | |