| Author | Martínez-Espinosa, Flor Ernestina | |
| Author | Ribeiro, Cláudio Tadeu Daniel | |
| Author | Alecrim, Wilson Duarte | |
| Access date | 2019-11-26T15:30:45Z | |
| Available date | 2019-11-26T15:30:45Z | |
| Document date | 2004 | |
| Citation | MARTINEZ-ESPINOZA, Flor Ernestina; RIBEIRO, Cláudio Tadeu Daniel; ALECRIM, Wilson Duarte. Malaria during Pregnancy in a Reference Centre from the Brazilian Amazon: Unexpected Increase in the Frequency of Plasmodium falciparum Infections. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 99, n. 1, p. 19-21, Feb. 2004. | pt_BR |
| ISSN | 0074-0206 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/37393 | |
| Language | eng | pt_BR |
| Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Malária | pt_BR |
| Subject in Portuguese | Gravidez | pt_BR |
| Subject in Portuguese | Plasmodium falciparum | pt_BR |
| Subject in Portuguese | Plasmodium vivax | pt_BR |
| Subject in Portuguese | Amazônia brasileira | pt_BR |
| Subject in Portuguese | América do Sul | pt_BR |
| Subject in Portuguese | Transmissão instável | pt_BR |
| Title | Malaria during Pregnancy in a Reference Centre from the Brazilian Amazon: Unexpected Increase in the Frequency of Plasmodium falciparum Infections | pt_BR |
| Type | Article | |
| DOI | 10.1590/S0074-02762004000100003 | |
| Abstract | Malaria remains globally the most important parasitic disease of man. Data on its deleterious effects during
pregnancy have been extensively documented in hyperendemic, holoendemic, and mesoendemic areas – from Africa
and Asia – where Plasmodium falciparum is responsible for almost all infections. However, knowledge about malaria
during pregnancy in areas where transmission is unstable and P. vivax is the most prevalent species, such as the
Brazilian Amazon, is scarce. Here, we report a preliminary cross sectional descriptive study, carried out at the
Fundação de Medicina Tropical do Amazonas, a reference centre for diagnosis and treatment of tropical diseases in
the west-Amazon (Manaus, Brazil). A total of 1699 febrile childbearing age women had positive thick blood smears
to Plasmodium species, between January and November 1997: 1401 (82.5%) were positive for P. vivax, 286 (16.8%)
for P. falciparum and 12 (0.07%) carried mixed infections. From the malarious patients, 195 were pregnant. The ratio
of P. falciparum to P. vivax infections in the group of non-pregnant infected women was 1:5.6 while it was 1:2.3 in that
of pregnant infected ones. Similar rates or even proportionally more vivax infections during pregnancy were
expected to occur, in function of the contraindication of primaquine with the resulting increased P. vivax relapse
rates. Such an observation suggests that the mechanism of resistance/susceptibility to infection and/or malaria
pathogenesis in pregnant women may differ according to Plasmodium species and that the extensively described
increase in the frequencies of malaria infection during pregnancy may be specifically due to P. falciparum infection. | pt_BR |
| Affilliation | Fundação de Medicina Tropical do Amazonas. Manaus, AM, Brasil / Centro Universitário Nilton Lins, Manaus, AM, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro Colaborador da WHO Para Pesquisa e Treinamento em Imunulogia de Doenças Parasitárias. Rio de Janeiro, RJ, Brasil. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação de Medicina Tropical do Amazonas. Manaus, AM, Brasil / Centro Universitário Nilton Lins, Manaus, AM, Brasil. | pt_BR |
| Subject | Malaria | pt_BR |
| Subject | Pregnancy | pt_BR |
| Subject | Plasmodium falciparum | pt_BR |
| Subject | Plasmodium vivax | pt_BR |
| Subject | Instable transmission | pt_BR |
| Subject | Brazilian Amazon | pt_BR |
| Subject | South America | pt_BR |
| e-ISSN | 1678-8060 | |
