| Author | Balassiano, Ilana Teruszkin | |
| Author | Santos-Filho, Joaquim dos | |
| Author | Oliveira, Márcia Pinto Barros de | |
| Author | Ramos, Maria Catarina | |
| Author | Japiassu, André M. | |
| Author | Reis, Alessandro Mendonça dos | |
| Author | Brazier, Jon S. | |
| Author | Ferreira, Eliane de Oliveira | |
| Author | Domingues, Regina Maria Cavalcanti Pilotto | |
| Access date | 2019-11-28T12:36:55Z | |
| Available date | 2019-11-28T12:36:55Z | |
| Document date | 2010 | |
| Citation | BALASSIANO, Ilana Teruszkin et al. An outbreak case of Clostridium difficile-associated diarrhea among elderly inpatients of an intensive care unit of a tertiary hospital in Rio de Janeiro, Brazil. Diagnostic Microbiology and Infectious Disease, v. 68, p. 449-455, 2010. | pt_BR |
| ISSN | 0732-8893 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/37438 | |
| Description | André M. Japiassu. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento. | pt_BR |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | open access | |
| Title | An outbreak case of Clostridium difficile-associated diarrhea among elderly inpatients of an intensive care unit of a tertiary hospital in Rio de Janeiro, Brazil | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.diagmicrobio.2010.07.017 | |
| Abstract | The aim of this study was to investigate Clostridium difficile-associated diarrhea (CDAD) in an intensive care unit (ICU) of a tertiary hospital in Rio de Janeiro, Brazil, and to characterize epidemiologically C. difficile strains obtained from an outbreak of CDAD. Within almost a 4-year surveillance period, CDAD incidence was determined for the first time in Brazil, and a 3-fold increase was observed in the average rate of CDAD, featuring an outbreak. About 80% of the patients were over 65 years. The main antibiotic that could be probably associated to CDAD was piperacillin/tazobactam. Four toxigenic strains were isolated, 3 from stools and 1 from environmental samples. They were all resistant to clindamycin and fluoroquinolones. Fingerprinting analysis revealed their distribution between 2 different polymerase chain reaction ribotypes, with one of them being exclusively found in Brazil. It was possible to detect cross-infection and environmental contamination in the ICU. Our results highlight the importance of a continuous CDAD surveillance in the hospitals, especially when a risk group is exposed. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Microbiologia Professor Paulo de Góes. Laboratório de Biologia de Anaeróbios. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Microbiologia Professor Paulo de Góes. Laboratório de Biologia de Anaeróbios. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | INFECTO Consultoria. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Serviço de Controle de Infecção Hospitalar de hospital terciário privado. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Unidade de Terapia Intensiva de hospital terciário privado. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Laboratório de Análises Clínicas de hospital terciário privado. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | University Hospital of Wales. Anaerobe Reference Unit. Cardiff, UK. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro, Xerém. Instituto de Microbiologia Professor Paulo de Góes. Duque de Caxias, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Microbiologia Professor Paulo de Góes. Laboratório de Biologia de Anaeróbios. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Clostridium difficile | pt_BR |
| Subject | Clostridium difficile-associated diarrhea | pt_BR |
| Subject | Intensive care unit | pt_BR |
| Subject | Elderly inpatients | pt_BR |
| e-ISSN | 1879-0070 | |
| Embargo date | 2020-11-28 | |
