| Author | Monteiro, Lucia Maria Costa | |
| Author | Cruz, Glaura Nisya de Oliveira | |
| Author | Fontes, Juliana Marin | |
| Author | Araujo, Grace Ferreira de | |
| Author | Ventura, Tayane | |
| Author | Monteiro, Ana Carolina | |
| Author | Moreira, Maria Elisabeth Lopes | |
| Access date | 2019-12-04T14:48:39Z | |
| Available date | 2019-12-04T14:48:39Z | |
| Document date | 2019 | |
| Citation | MONTEIRO, Lucia Maria Costa et al. Neurogenic bladder in the settings of congenital Zika syndrome: a confirmed and unknown condition for urologists. Journal of Pediatric Urology, v. 15, n. 5. p. 450.e1-450.e7, 2019. | pt_BR |
| ISSN | 1477-5131 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/37572 | |
| Language | por | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Zika vírus | pt_BR |
| Subject in Portuguese | Microcefalia | pt_BR |
| Subject in Portuguese | Infecção pelo Zika vírus | pt_BR |
| Title | Neurogenic bladder in the settings of congenital Zika syndrome: a confirmed and unknown condition for urologists | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.jpurol.2019.04.018 | |
| Abstract | INTRODUCTION: Congenital Zika syndrome (CZS) is a recently discovered condition that affects central nervous system structures that control the lower urinary tract. The first cases of neurogenic bladder (NB) were recently reported as a sequalae of CZS in neurologically impaired children. OBJECTIVE: Our goal is to further evaluate NB in the setting of CZS, identifying urological risk indicators in hopes that early diagnosis will mitigate the impact of the disease. STUDY DESIGN: Urological assessment was performed in all patients with CZS and neurological impairment who were referred to our urodynamic clinic between June 2016 and May 2018. Neurogenic bladder was confirmed by urodynamic evaluation, and urological risk was based on urodynamic results. RESULTS: Sixty-nine patients with CZS were tested. The majority (63 patients, 91.3%) presented with overactive bladder with increased pressures and reduced capacity for age (table 1). Different urodynamic patterns were observed, and the association of reduced bladder capacity for age, high bladder-filling pressure, and increased postvoid residual were frequently observed. DISCUSSION:
NB continues to be consistently diagnosed in our cohort of CZS, mostly with high-risk indicators for renal impairment. When not intervened upon in a timely manner, NB can cause progressive damage to the urinary tract, but the lack of knowledge that CZS causes NB delays investigation and treatment. Parents and health professionals will need to be sensitized to the risks that ZIKV can pose to the urinary tract so that appropriate therapies are initiated to prevent irreversible renal damage. CONCLUSION: NB is a common condition among our patients with CZS and microcephaly. This is a new cause of NB, unknown to urologists. While further investigation is necessary to understand long-term disease behavior and therapeutic response, increased knowledge among urologists may help to reduce morbidity related to untreated NB and to mitigate the disease burden for patients and families. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior. Brasília, DF, Brasil / Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | University of California, Los Angeles. Division of Pulmonary and Critical Care Medicine. CA, USA. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Congenital Zika syndrome | pt_BR |
| Subject | Microcephaly | pt_BR |
| Subject | Neurogenic bladder | pt_BR |
| Subject | Urinary tract infection | pt_BR |
| Subject | Zika virus | pt_BR |
| Embargo date | 2200-01-01 | |
