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AutorHespanhol, Renata
AutorSoeiro, Maria de Nazaré C.
AutorMeuser, Marcos B.
AutorMeirelles, Maria de Nazareth S. L.
AutorCôrte-Real, Suzana
Fecha de acceso2019-12-10T12:19:09Z
Fecha de disponibilización2019-12-10T12:19:09Z
Fecha de publicación2005
ReferenciaHESPANHOL, Renata C. et al. The Expression of Mannose Receptors in Skin Fibroblast and Their Involvement in Leishmania (L.) amazonensis Invasion. The Journal of Histochemistry & Cytochemistry, v. 53, n.1, p. 35-44, 2005.pt_BR
ISSN0022-1554pt_BR
URIhttps://www.arca.fiocruz.br/handle/icict/37735
Idiomaengpt_BR
EditorSAGE Publicationspt_BR
Derechos de autorrestricted access
Palabras clave en PortuguésLeishmania ( L. ) amazonensispt_BR
Palabras clave en PortuguésFibroblastos da pelept_BR
Palabras clave en PortuguésReceptores de mannosept_BR
Palabras clave en PortuguésMicroscopia eletrônica de transmissãopt_BR
TítuloThe Expression of Mannose Receptors in Skin Fibroblast and Their Involvement in Leishmania (L.) amazonensis Invasionpt_BR
Tipo del documentoArticle
DOI10.1369/jhc.4A6384.2005
Resumen en InglésLeishmania are protozoa that invade mononuclear phagocytes with the involvement of different ligand-receptor systems, including mannose receptors. Until now, scant data are available concerning the mechanisms that govern the infection of Leishmania in other host cell types such as fibroblasts. Our aim was to analyze the expression of mannose receptors in primary cultures of skin fibroblasts (SF) further characterizing their role during the invasion of promastigotes of Leishmania ( L .) amazonensis . Both fluorescent, light, and electron microscopy assays revealed that SF have mannose receptors since they bound and internalized mannosylated ligands in addition to being positively labeled by fuc-BSA-FITC probes. D -mannose competition assays revealed the participation of mannose receptors during the parasite association with SF presenting upregulated receptor expression during the initial steps of the infection. After longer periods of Leishmania :fibroblasts contact, the modulation noted in the host mannose receptors was reverted concomitantly to the infection control, suggesting that the parasites were required for the alteration maintenance and providing evidences that the SF may display microbicidal mechanisms to control the Leishmania infection.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultra-estrutura e Biologia Celular. Laboratório de Ultra-estrutura Celular. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultra-estrutura e Biologia Celular. Laboratório de Ultra-estrutura Celular. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultra-estrutura e Biologia Celular. Laboratório de Ultra-estrutura Celular. Rio de Janeiro, RJ, Brasil.pt_BR
Palavras clave en InglêsSkin fibroblastspt_BR
Palavras clave en InglêsMannose receptorspt_BR
Palavras clave en InglêsLeishmania ( L. ) amazonensispt_BR
Palavras clave en InglêsTransmission electron microscopypt_BR
e-ISSN1551-5044


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