| Author | López-Camelo, Jorge S. | |
| Author | Orioli, Iêda M. | |
| Author | Dutra, Maria da Graça | |
| Author | Nazer-Herrera, Julio | |
| Author | Rivera, Nelson | |
| Author | Ojeda, María Elena | |
| Author | Canessa, Aurora | |
| Author | Wettig, Elisabeth | |
| Author | Fontannaz, Ana María | |
| Author | Mellado, Cecília | |
| Author | Castilla, Eduardo E. | |
| Access date | 2019-12-12T14:30:17Z | |
| Available date | 2019-12-12T14:30:17Z | |
| Document date | 2005 | |
| Citation | LÓPEZ-CAMELO, Jorge S. et al. Reduction of Birth Prevalence Rates of Neural Tube Defects After Folic Acid Fortification in Chile. American Journal of Medical Genetics, 135A, p. 120-125, 2005. | pt_BR |
| ISSN | 0148-7299 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/37903 | |
| Language | eng | pt_BR |
| Publisher | Wiley 12 Months | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Ácido fólico | pt_BR |
| Subject in Portuguese | Fortificação de alimentos | pt_BR |
| Subject in Portuguese | Fortificação da farinha de trigo | pt_BR |
| Subject in Portuguese | População chilena | pt_BR |
| Subject in Portuguese | Defeitos do tubo neural | pt_BR |
| Subject in Portuguese | Espinha bífida | pt_BR |
| Subject in Portuguese | Anencefalia | pt_BR |
| Title | Reduction of birth prevalence rates of neural tube defects after folic acid fortification in Chile | pt_BR |
| Type | Article | |
| DOI | 10.1002/ajmg.a.30651 | |
| Abstract | To verify whether the decreasing neural tube defects birth prevalence rates in Chile are due to folic acid fortification or to pre-existing decreasing trends, we performed a population survey using a network of Estudio Colaborativo Latino Americano de Malformaciones Congenitas (ECLAMC, Latin American Collaborative Study of Congenital Malformations) maternity hospitals in Chile, between the years 1982 and 2002. Within each maternity hospital, birth prevalence rates of spina bifida and anencephaly were calculated from two pre-fortification periods (1982-1989 and 1990-2000), and from one fortified period (2001-2002). There was no historical trend for spina bifida birth prevalence rates before folic acid fortification, and there was a 51% (minimum 27%, maximum 66%) decrease in the birth prevalence rates of this anomaly in the fortified period. The relative risks of spina bifida were homogeneous among hospitals in the two period comparisons. There was no historical trend for the birth prevalence of anencephaly comparing the two pre-fortified periods, but the relative risks were heterogeneous among hospitals in this comparison. There was a 42% (minimum 10%, maximum 63%) decrease in the birth prevalence rate of anencephaly in the fortified period as compared with the immediately pre-fortified period, with homogeneous relative risks among hospitals. Within the methodological constraints of this study we conclude that the birth prevalence rates for both spina bifida and anencephaly decreased as a result of folic acid fortification, without interference of decreasing secular trends. | pt_BR |
| Affilliation | Estudo Colaborativo Latino Americano de Malformações Congênitas. ECLAMC at IMBICE. Instituto Multidisciplinario de Biologia Celular, La Plata, Argentina / ECLAMC at CEMIC, Centro de Educación Médica e Investigación Clínica, Buenos Aires, Argentina. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. ECLAMC at Departamento de Genética. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. ECLAMC at Departamento de Genética. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | ECLAMC at Hospital Universitario J.J. Aguirre. Santiago, Chile. | pt_BR |
| Affilliation | ECLAMC at Hospital Naval Almirante Nef, Valparaiso. Chile. | pt_BR |
| Affilliation | ECLAMC at Hospital Regional de Rancagua. Chile. | pt_BR |
| Affilliation | ECLAMC at Hospital Base de Linares. Chile. | pt_BR |
| Affilliation | ECLAMC at Hospital de Puerto Montt. Chile. | pt_BR |
| Affilliation | ECLAMC at Hospital Sótero del Río. Santiago, Chile. | pt_BR |
| Affilliation | ECLAMC at Hospital Sótero del Río. Santiago, Chile. | pt_BR |
| Affilliation | ECLAMC at CEMIC, Centro de Educación Médica e Investigación Clínica, Buenos Aires, Argentina / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. ECLAMC at Departamento de Genética. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Folic acid | pt_BR |
| Subject | Food fortification | pt_BR |
| Subject | Wheat flour fortification | pt_BR |
| Subject | Chilean population | pt_BR |
| Subject | Neural tube defects | pt_BR |
| Subject | Spina bifida | pt_BR |
| Subject | Anencephaly | pt_BR |
| e-ISSN | 1096-8628 | |
| Embargo date | 2025-01-01 | |
| xmlui.metadata.dc.subject.ods | 02 Fome zero e agricultura sustentável | |
