| Author | Peetluk, Lauren S. | |
| Author | Rebeiro, Peter F. | |
| Author | Santos, Marcelo Cordeiro | |
| Author | Kritski, Afranio | |
| Author | Andrade, Bruno de Bezerril | |
| Author | Durovni, Betina | |
| Author | Calvacante, Solange | |
| Author | Arriaga Gutiérrez, María Belen | |
| Author | Turner, Megan M. | |
| Author | Figueiredo, Marina C. | |
| Author | Rolla, Valeria C. | |
| Author | Sterling, Timothy R. | |
| Author | Regional Prospective Observational Research in Tuberculosis (RePORT)Brazil network | |
| Access date | 2019-12-16T17:52:12Z | |
| Available date | 2019-12-16T17:52:12Z | |
| Document date | 2019 | |
| Citation | PEETLUK, Lauren S. et al. Lack of weight gain during the first two months of treatment and HIV independently predict unsuccessful treatment outcomes in tuberculosis. Journal of Infectious Diseases, p. 1-9, 2019. | pt_BR |
| ISSN | 0022-1899 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/37977 | |
| Sponsorship | Departamento de Ciência e Tecnologia, Secretaria de
Ciência e Tecnologia, Ministério da Saúde, Brazil (grant
25029.000507/2013-07 to V. C. R.), the National Institutes
of Allergy and Infectious Diseases (grants U01-AI069923
and K01-AI131895 to P. F. R), and the National Center for
Advancing Translational Sciences (Clinical and Translational
Science Award (CTSA) award TL1TR000447 to L. S. P.). | pt_BR |
| Language | eng | pt_BR |
| Publisher | Oxfor University Press | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | Tuberculose | pt_BR |
| Subject in Portuguese | HIV | pt_BR |
| Subject in Portuguese | Mudanças de peso corporal | pt_BR |
| Subject in Portuguese | Resultado do tratamento; | pt_BR |
| Subject in Portuguese | Estudo de observação | pt_BR |
| Title | Lack of weight gain during the first two months of treatment and HIV independently predict unsuccessful treatment outcomes in tuberculosis | pt_BR |
| Type | Article | |
| DOI | 10.1093/infdis/jiz595 | pt_BR |
| Abstract | Weight change may inform tuberculosis treatment response, but its predictive power may be confounded by human immunodeficiency virus (HIV). Methods. We prospectively followed up adults with culture-confirmed, drug-susceptible, pulmonary tuberculosis receiving standard 4-drug therapy (isoniazid, rifampin, pyrazinamide, and ethambutol) in Brazil. We examined median weight change 2 months after treatment initiation by HIV status, using quantile regression, and unsuccessful tuberculosis treatment outcome (treatment failure, tuberculosis recurrence, or death) by HIV and weight change status, using Cox regression. Results. Among 547 participants, 102 (19%) were HIV positive, and 35 (6%) had an unsuccessful outcome. After adjustment for confounders, persons living with HIV (PLWH) gained a median of 1.3 kg (95% confidence interval [CI], −2.8 to .1) less than HIVnegative individuals during the first 2 months of tuberculosis treatment. PLWH were at increased risk of an unsuccessful outcome (adjusted hazard ratio, 4.8; 95% CI, 2.1–10.9). Weight change was independently associated with outcome, with risk of unsuccessful outcome decreasing by 12% (95% CI, .81%–.95%) per 1-kg increase. Conclusions. PLWH gained less weight during the first 2 months of tuberculosis treatment, and lack of weight gain and HIV independently predicted unsuccessful tuberculosis treatment outcomes. Weight, an easily collected biomarker, may identify patients who would benefit from alternative treatment strategies. | pt_BR |
| Affilliation | Vanderbilt University School of Medicine. Department of Medicine. Division of Epidemiology. Nashville, Tennessee, USA. | pt_BR |
| Affilliation | Vanderbilt University School of Medicine. Department of Medicine. Division of Epidemiology. Nashville, Tennessee, USA / Vanderbilt University School of Medicine. Division of Infectious Diseases, Department of Medicine. Nashville, Tennessee, USA. | pt_BR |
| Affilliation | Fundação Medicina Tropical Dr Heitor Vieira Dourado. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Manaus, AM, Brasil. | pt_BR |
| Affilliation | Universidade do Estado do Amazonas. Manaus, AM, Brasil / Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Vanderbilt University School of Medicine. Department of Medicine. Division of Infectious Diseases. Nashville, Tennessee, USA / Fundação José Silveira. Instituto Brasileiro para Investigação da Tuberculose. Multinational Organization Network Sponsoring Translational and Epidemiological Research. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Salvador. Laureate Universities. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Faculdade de Tecnologia e Ciências. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Secretaria Municipal de Saúde do Rio de Janeiro. Clínica da Família Rinaldo Delamare. Rocinha, RJ, Brasil. | pt_BR |
| Affilliation | Fundação José Silveira. Instituto Brasileiro para Investigação da Tuberculose. Multinational Organization Network Sponsoring Translational and Epidemiological Research. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Vanderbilt University School of Medicine. Division of Infectious Diseases, Department of Medicine. Nashville, Tennessee, USA. | pt_BR |
| Affilliation | Vanderbilt University School of Medicine. Division of Infectious Diseases, Department of Medicine. Nashville, Tennessee, USA. | pt_BR |
| Affilliation | Secretaria Municipal de Saúde do Rio de Janeiro. Clínica da Família Rinaldo Delamare. Rocinha, RJ, Brasil. | pt_BR |
| Affilliation | Vanderbilt University School of Medicine. Division of Infectious Diseases, Department of Medicine. Nashville, Tennessee, USA. | pt_BR |
| Subject | Tuberculosis | pt_BR |
| Subject | HIV | pt_BR |
| Subject | Body weight changes | pt_BR |
| Subject | Treatment outcome | pt_BR |
| Subject | Observational study | pt_BR |
