Author | Tedesco, R. C. | |
Author | Smith, R. L. | |
Author | Corte-Real, Suzana | |
Author | Calabrese, K. S. | |
Access date | 2019-12-17T11:45:24Z | |
Available date | 2019-12-17T11:45:24Z | |
Document date | 2005 | |
Citation | TEDESCO, R. C. et al. Ocular toxoplasmosis in mice: comparison of two routes of infection. Parasitology, v. 131, p. 303-307, 2005. | pt_BR |
ISSN | 0031-1820 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/38061 | |
Language | eng | pt_BR |
Publisher | Cambridge University Press | pt_BR |
Rights | restricted access | pt_BR |
Subject in Portuguese | Toxoplasma gondii | pt_BR |
Subject in Portuguese | Toxoplasmose Ocular | pt_BR |
Subject in Portuguese | Instilação | pt_BR |
Subject in Portuguese | Camundongos | pt_BR |
Title | Ocular toxoplasmosis in mice: comparison of two routes of infection | pt_BR |
Type | Article | pt_BR |
DOI | 10.1017/s003118200500781x | |
Abstract | This paper aims to test the influence of route of infection (intravitreal and instillation) on the course of ocular toxoplasmosis in mice, using the Toxoplasma gondii Me-49 strain. All mice inoculated intravitreally or by instillation presented the same pattern of infection. Using either route, parasites were observed in the retinal vessel with the formation of a glial reaction in the inner plexiforme layer and discontinuity of the pigmented epithelium of the retina 7 days after infection. However, when the intravitreal route was used a more intense inflammatory infiltrate was observed in the retina. The results suggest that inoculation route remarkably influences the inflammatory pattern in ocular toxoplasmosis and that the instillation route should be preferentially used in experimental infections in the murine ocular model of infection by T. gondii, specially with small animals where there is extensive needle damage, which is not observed in the instillation route. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultra-estrutura e Biologia Celular. Laboratório de Biologia Estrutural. Rio de Janeiro, RJ, Brasil / Universidade Federal de São Paulo. Departamento de Morfologia. Disciplina de Anatomia Topográfica e Descritiva. São Paulo, SP, Brasil. | pt_BR |
Affilliation | Universidade Federal de São Paulo. Departamento de Morfologia. Disciplina de Anatomia Topográfica e Descritiva. São Paulo, SP, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultra-estrutura e Biologia Celular. Laboratório de Biologia Estrutural. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Protozoologia. Laboratório de Imunomodulação. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Toxoplasma gondii | pt_BR |
Subject | Ocular toxoplasmosis | pt_BR |
Subject | Intravitreal | pt_BR |
Subject | Instillation | pt_BR |
Subject | Mouse model | pt_BR |
e-ISSN | 1469-8161 | |
Embargo date | 2022-01-01 | |