| Author | Silva, C. M. D. | |
| Author | Costi, C. | |
| Author | Costa, C. | |
| Author | Michelon, C. | |
| Author | Oravec, R. | |
| Author | Ramos, A. B. | |
| Author | Niel, Christian | |
| Author | Rossetti, M. L. | |
| Access date | 2019-12-17T12:50:50Z | |
| Available date | 2019-12-17T12:50:50Z | |
| Document date | 2005 | |
| Citation | SILVA, C. M. D. et al. Low rate of occult hepatitis B virus infection among anti-HBc positive blood donors living in a low prevalence region in Brazil. Journal of Infection, v. 51, p. 24-29, 2005. | pt_BR |
| ISSN | 0163-4453 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/38641 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Doadores de sangue | pt_BR |
| Subject in Portuguese | Vírus da Hepatite B | pt_BR |
| Subject in Portuguese | DNA da Hepatite B | pt_BR |
| Subject in Portuguese | Marcadores sorológicos | pt_BR |
| Subject in Portuguese | Carga viral | pt_BR |
| Title | Low rate of occult hepatitis B virus infection among anti-HBc positive blood donors living in a low prevalence region in Brazil | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.jinf.2004.07.007 | |
| Abstract | Objective. The aim of this study was to determine the rate of occult hepatitis B virus (HBV) infection among blood donors living in a geographic region of low (5.6%) anti-HBc prevalence. Subjects and methods. Sera from 150 candidate blood donors whose blood was rejected due to total anti-HBc reactivity (despite absence of HBsAg) were tested for anti-HBs and IgM anti-HBc antibodies, as well as for HBeAg/anti-HBe. Serum HBV DNA was sought by using a PCR assay able to amplify part of the surface gene. Viral load was measured in the PCR positive samples. Results. The pattern ’anti-HBc alone’ (without HBsAg and anti-HBs antibodies) was foundin 64(42.7%) subjects.IgManti-HBc and anti-HBe antibodies were detected in 2(1.3%) and 80 (53.3%) samples, respectively. No sample was HBeAg-reactive. HBV DNA was repeatedly found in five(3.3%) samples, three of which were anti-HBs positive and two antiHBs negative. All five HBV DNA positive samples showed alow viral load (!1000 copies/ml). Conclusions. The data indicated a low rate of occult infection among anti-HBc positive, HBs Ag negative blood donors living in a region of low prevalence of infection. Viral load was very low in all HBV infected subjects. | pt_BR |
| Affilliation | Fundação Estadual de Produtividade e Pesquisa para Saúde Pública. Centro de Desenvolvimento Científico e Tecnológico. Porto Alegre, RS, Brasil / Universidade Luterana do Brasil. Canoas, RS, Brasil. | pt_BR |
| Affilliation | Fundação Estadual de Produtividade e Pesquisa para Saúde Pública. Centro de Desenvolvimento Científico e Tecnológico. Porto Alegre, RS, Brasil. | pt_BR |
| Affilliation | Fundação Estadual de Produtividade e Pesquisa para Saúde Pública. Centro Hemoterápico do Rio Grande do Sul. Porto Alegre, RS, Brasil. | pt_BR |
| Affilliation | Fundação Estadual de Produtividade e Pesquisa para Saúde Pública. Centro de Desenvolvimento Científico e Tecnológico. Porto Alegre, RS, Brasil. | pt_BR |
| Affilliation | Fundação Estadual de Produtividade e Pesquisa para Saúde Pública. Centro Hemoterápico do Rio Grande do Sul. Porto Alegre, RS, Brasil / Laboratório Weinmann. Porto Alegre, RS, Brasil. | pt_BR |
| Affilliation | Fundação da Universidade de Cardiologia. Alvorada, RS, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Estadual de Produtividade e Pesquisa para Saúde Pública. Centro de Desenvolvimento Científico e Tecnológico. Porto Alegre, RS, Brasil / Universidade Luterana do Brasil. Canoas, RS, Brasil. | pt_BR |
| Subject | Blood donors | pt_BR |
| Subject | Hepatitis B virus | pt_BR |
| Subject | HBV DNA | pt_BR |
| Subject | Serological markers | pt_BR |
| Subject | Viral load | pt_BR |
| e-ISSN | 1532-2742 | |
| Embargo date | 2025-01-01 | |
