| Author | Nunes, Marise P. | |
| Author | Cysne-Finkelstein, Lea | |
| Author | Monteiro, Bruna C. | |
| Author | Souza, Daniel M. de | |
| Author | Gomes, Nitza A. | |
| Author | Reis, George A. dos | |
| Access date | 2019-12-17T16:14:32Z | |
| Available date | 2019-12-17T16:14:32Z | |
| Document date | 2005 | |
| Citation | NUNES, Marise P. et al. CD40 signaling induces reciprocal outcomes in Leishmania-infected macrophages; roles of host genotype and cytokine milieu. Microbes and Infection, v. 7, p. 78-85, 2005. | pt_BR |
| ISSN | 1286-4579 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/38659 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Leishmania major | pt_BR |
| Subject in Portuguese | Células T CD4 + | pt_BR |
| Subject in Portuguese | Macrófago | pt_BR |
| Subject in Portuguese | Interleucina | pt_BR |
| Subject in Portuguese | Antígenos CD40 | pt_BR |
| Subject in Portuguese | Ligante de CD40 | pt_BR |
| Title | CD40 signaling induces reciprocal outcomes in Leishmania-infected macrophages; roles of host genotype and cytokine milieu | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.micinf.2004.08.022 | |
| Abstract | We investigated the influence of CD40-CD40 ligand-mediated signaling on induction of microbicidal activity against Leishmania major in macrophages from resistant (B6) and susceptible (BALB) mouse strains. CD40 engagement induced leishmanicidal activity in resistant macrophages, but increased parasite replication in susceptible macrophages. CD40 engagement induced comparable TNF-alpha production in macrophages from both strains. However, increased IL-10 production was restricted to susceptible macrophages. Increased parasite replication in susceptible macrophages was prevented by a neutralizing anti-IL-10 antibody. In the presence of IFN-gamma, CD40 engagement induced Leishmania killing by macrophages from both strains. Therefore, the outcome of CD40 signaling on effector responses against L. major depends on host genotype and the cytokine milieu, and a source of IFN-gamma is required for a protective response. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Biofísica Carlos Chagas Filho. Programa de Imunobiologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Biofísica Carlos Chagas Filho. Programa de Imunobiologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Biofísica Carlos Chagas Filho. Programa de Imunobiologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Biofísica Carlos Chagas Filho. Programa de Imunobiologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Leishmania major | pt_BR |
| Subject | CD40 | pt_BR |
| Subject | Macrophage | pt_BR |
| Subject | CD40 ligand | pt_BR |
| Subject | IFN-y | pt_BR |
| Subject | CD4+ T cells | pt_BR |
| DeCS | Antígenos CD40 | pt_BR |
| DeCS | Ligante de CD40 | pt_BR |
| e-ISSN | 1769-714X | |
| Embargo date | 2025-01-01 | |
