| Author | Castro, Ana R. C. Motta | |
| Author | Martins, Regina M. B. | |
| Author | Yoshida, Clara F. T. | |
| Author | Teles, Sheila A. | |
| Author | Paniago, Annamaria M. | |
| Author | Lima, Kátia M. B. | |
| Author | Gomes, Selma A. | |
| Access date | 2019-12-19T13:25:03Z | |
| Available date | 2019-12-19T13:25:03Z | |
| Document date | 2005 | |
| Citation | CASTRO, Ana R. C. Motta et al. Hepatitis B Virus Infection in Isolated Afro-Brazilian Communities. Journal of Medical Virology, v. 77, p. 188-193, 2005. | pt_BR |
| ISSN | 0146-6615 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/38705 | |
| Language | eng | pt_BR |
| Publisher | Wiley 12 Months | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | Vírus da Hepatite B | pt_BR |
| Subject in Portuguese | Afro-brazileiros | pt_BR |
| Subject in Portuguese | Prevalência | pt_BR |
| Subject in Portuguese | Fatores de risco | pt_BR |
| Subject in Portuguese | Genótipos | pt_BR |
| Title | Hepatitis B Virus Infection in Isolated Afro-Brazilian Communities | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1002/jmv.20435 | |
| Abstract | The prevalence and genotypes of hepatitisBvirus
(HBV) have distinct geographical distribution.
In Brazil, some African-descendants have been
maintained as small isolated communities since
the slavery period. In this study, HBV infection
among these communities of African origin was
examined. Individuals (1,058) living in 12 communities
were interviewed and serum samples
screened for the presence of HBV markers.
HBsAg-positive sera were tested for HBV DNA
by PCR and positive samples were genotyped by
restriction fragment length polymorphism(RFLP).
The overall prevalence of HBV infection was
19.8% (95% CI: 17.5–22.3), ranging from 5.5% to
42.4%, depending on the communities studied.
Multivariate analysis of risk factors showed that
increasing age, family history of hepatitis, and
sexual activity were associated significantly with
this infection. HBsAg was detected in 23/1,058
(2.2%) individuals. HBVDNAwas present in 2/2 of
HBeAg-positive serum samples and in 18/21
(85.7%) anti-HBe-positive samples. All HBV isolates
belonged to genotype A, subtype Aa. Three
RFLP patterns were identified: AI (17 isolates), AIV
(1 isolate), and AVI (2 isolates). These findings
suggest a common introduction of HBV during
the slave trade from Africa to Brazil. | pt_BR |
| Affilliation | Universidade Federal de Mato Grosso do Sul. Departamento de Farmácia Bioquímica. Campo Grande, MS, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Laboratório de Virologia. Goiânia, GO, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Universidade Federal de Goiás. Faculdade de Enfermagem. Goiânia, GO, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Mato Grosso do Sul. Departamento de Doenças Infecto Parasitárias. Campo Grande, MS, Brasil. | pt_BR |
| Affilliation | Secretaria de Saúde do Estado Mato Grosso do Sul. Coordenadoria de Imunizações. Campo Grande, MS, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil | pt_BR |
| Subject | HBV | pt_BR |
| Subject | Afro-Brazilian | pt_BR |
| Subject | Prevalence | pt_BR |
| Subject | Risk factors | pt_BR |
| Subject | Genotypes | pt_BR |
| e-ISSN | 1096-9071 | |
| Embargo date | 2025-01-01 | |
